Interaction study between levofloxacin and omeprazole using urinary pharmacokinetic data

The objective of this study was to observe the drug interaction between levofloxacin and omeprazole using urinary excretion data. Levofloxacin tablet and omeprazole capsule were administered separately as well as in combination in fasting condition with a wash out period of two weeks after each administration. Urine was collected at different time intervals of 0, 0-2, 2-4, 4-8, 8-12, 12-24, 24-36 and 36-48 hr post-dose and analyzed using a validated HPLC with UV detection. Different pharmacokinetic parameters for both drugs were determined using non-compartmental method. The maximum rate of excretion [R[max]] of levofloxacin was not decreased significantly when co-administered with omeprazole [p>0.05]. Similarly no significant difference [p = 0.350] was observed for R[max] of omeprazole when co-administered with levofloxacin. Again the fraction of levofloxacin excreted [f[e]/f] was not changed significantly [p = 0.953] due to the co-administration of omeprazole. Similarly fraction of omeprazole excreted [f[e] /f] also remained unaffected [p = 0.672] when co-administered with levofloxacin. No significant change was observed for the area under the rate of excretion versus midpoint of time interval curve from zero to 48 hours [AURC[0-48] for levofloxacin and omeprazole [p = 0.816 and 0.792 respectively] when administered separately and co-administered with each other. The study clearly revealed that levofloxacin and omeprazole do not undergo any kind of interactions when administered together. So it can be concluded that these two drugs can be prescribed together to achieve optimum therapeutic activity

Effect of tamarindus indica fruits on blood pressure and lipid-profile in human model: an in vivo approach

Fruits of Tamarindus indica were evaluated for their effects on lipid profile, systolic and diastolic blood pressure and body weight in human subjects. Dried and pulverized pulp of T. indica fruits, at a dose of 15 mg/kg body weight, was found to reduce total cholesterol level [p = 0.031] and LDL-cholesterol level [p = 0.004] to a significant extent. Though the fruits exerted no conspicuous effect on body weight and systolic blood pressure, it significantly reduced the diastolic pressure as confirmed by independent sample t-test at 5% significance level