Résumé
Aim: In the present study, Sumatriptan succinate was formulated as oral elementary osmotic pump with a zero-order drug release profile. Methodology: The effect of different formulation variables i.e. different types of osmogens, concentrations of osmogen and concentration of coating solution were studied. The in vitro evaluation was carried out in different release media. Result: Highest percentage of drug release was observed at high concentration of mannitol i.e., 1:3 (drug: mannitol). Osmogen with low osmotic pressure (38 atm) showed 71.01% zero-order drug release for 12 hours when compared to that of the osmogen with high osmotic pressure (356 atm) which showed 67.38% of release by zero order. Conclusion: Elementary osmotic pump tablets of Sumatriptan succinate were able to deliver zero-order release up to 12 hours independent of pH of dissolution media and have overcome the problem of chronotherapeutic effect.
Résumé
Observations, having clinical and therapeutic implications, with the use of noninvasive continuous Transcutaneous arterial oxygen monitoring in sick newborns are being reported, Crying, bottle feeding, putting up an intravenous drip and opening of the incubator ports, were all associated with a significant fall in arterial oxygen tension in sick neonates. Hyperoxemia was seen with fraction of inspiratory oxygen [FiO2] as low as 30 to 35%. The continuous Transcutaneous arterial oxygen tension [TcPaO2] monitoring is recommended in sick newborns