RÉSUMÉ
This study was designed to determine the plasma levels of some antioxidants and trace elements in three severity groups of HIV patients compared with non-HIV-infected controls. The plasma levels of antioxidants [total antioxidant, albumin, bilirubin and uric acid] and trace elements [Mg, Fe, Zn, Mn, Cu, Cr, Cd and Se] were estimated spectrophotometrically in controls and patients with CD4 counts of <200; 200-499 and >/= 500 cells/microl. Uric acid and Zn were significantly higher, while vitamin E and all the trace elements [except Zn] were significantly lower in HIV-infected patients compared to healthy controls. The highest level of uric acid was observed in those with CD4 counts of <200 cells/ micro l. All the trace elements [except Zn] were higher in HIV subjects with a CD4 count of 200-499 cells/ micro l compared to >500 cells/ micro l. Only uric acid and Zn showed significant correlation with CD4 count. Based on the results of this study, we recommend routine assessment and appropriate supplementation of antioxidants/trace elements in HIV subjects. This supplementation is hoped to strengthen the immune system and reduce the adverse consequences of HIV- related oxidative stress