Résumé
Abstract Objective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis. Methods: A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in paraffin blocks from patients with and without adenomyosis. The sample contained 28 adenomyosis cases and 21 controls. Student's t-test and multivariate logistic regression tests were used for statistical analysis. Associations were considered significant at p < 0.05. Results: We found no significant association between adenomyosis and: smoking (p = 0.75), miscarriage (p = 0.29), number of previous pregnancies (p = 0.85), curettage (p = 0.81), pelvic pain (p = 0.72) and myoma (p = 0.15). However, we did find a relationship between adenomyosis and abnormal uterine bleeding (AUB) (p = 0.02) and previous cesarean section (p = 0.02). The mean TGF-β1 intensity (mean ± SD) in the ectopic endometrium of women with adenomyosis showed no significant association (184.17 ± 9.4 vs.184.66 ± 16.08, p = 0.86) from the topic endometrium of women without adenomyosis. Conclusion: TGF-β1 expression was not increased in the ectopic endometrium of women with adenomyosis.
Résumé
Objetivo: analisar a tendência temporal de mortalidade por neoplasia maligna de mama e de colo de útero em Passo Fundo, Rio Grande do Sul, Brasil, de 1999 a 2019. Métodos: estudo de série temporal a partir de dados do Sistema de Informações sobre Mortalidade; as taxas padronizadas de mortalidade foram calculados segundo idade e escolaridade e a tendência, avaliada por regressão de Prais-Winsten. Resultados: observou-se estabilidade nos coeficientes gerais de mortalidade por câncer de colo de útero (ß = -0,03; IC95% -0,08;0,02) e por câncer de mama (ß = -0,006; IC95% -0,02;0,01) no período avaliado; para ambos os tipos de câncer, identificou-se tendência ascendente dos coeficientes em mulheres com até 7 anos de estudo; entretanto, tendência estacionária foi observada na maior parte dos estratos etários analisados. Conclusão: mulheres em idades mais avançadas e com baixa escolaridade foram aquelas com pior prognóstico da doença.
Objetivo: analizar la tendencia temporal de la mortalidad por neoplasia maligna de mama y cuello uterino, de 1999 a 2019, en Passo Fundo, Rio Grande do Sul, Brasil. Métodos: estudio de series temporales a partir de datos del Sistema de Información de Mortalidad; las tasas estandarizadas se calcularon según la edad y la educación; y la tendencia, evaluada por regresión de Prais-Winsten. Resultados: hubo estabilidad en los coeficientes de mortalidad por cáncer de cuello uterino (ß = -0,03; IC95% -0,08;0,02) y por el cáncer de mama maligno (ß = -0,006; IC95% -0,02;0,01) a lo largo de la serie temporal; en ambos tipos de neoplasias se identificó una tendencia ascendente en mujeres con baja escolaridad; se observó una tendencia estacionaria en la mayoría de los estratos de edad analizados. Conclusión: las mujeres de mayor edad y con hasta 7 años de escolaridad fueran las de peor pronóstico.
Objective: to analyze the temporal trend of mortality due to malignant neoplasms of the breast and cervix from 1999 to 2019 in Passo Fundo, Rio Grande do Sul, Brazil. Methods: this was a time-series study based on data from the Mortality Information System; standardized rates were calculated according to age and schooling, and the temporal trend was assessed using Prais-Winsten regression. Results: the overall mortality coefficients for cervical cancer (ß= -0.03; 95%CI -0.08;0.02) and for breast cancer (ß = -0.006; 95%CI -0.02;0.01) were stable over the time series; in both types of neoplasms, a rising trend was identified in women with up to 7 years of schooling; on the other hand, a stationary trend was found in the majority of the age strata analyzed. Conclusion: older women and those with low levels of schooling had the worst prognosis.