Résumé
The in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to mouse skin. Increased drug concentration in donor compartment increased value of J but decreased value of Kp. Under similar conditions, values of J and Kp were lowered for dorsal skin as compared to abdominal skin, both for mice and guinea pig. The results indicate that verapamil can be administered transdermally.
Sujets)
Administration par voie cutanée , Animaux , Inhibiteurs des canaux calciques/administration et posologie , Cochons d'Inde , Souris , Peau/métabolisme , Vérapamil/administration et posologieRésumé
In vitro percutaneous absorption of atenolol was done in order to assess its feasibility for transdermal development across mouse and guinea pig skins using Keshary-Chien type of diffusion cell. Values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to those in mouse skin. When the concentration of drug in donor compartment was increased a decrease in Kp and increase in J value were observed with both the skins. Under the same conditions, values of J and Kp were lowered for dorsal skin compared to abdominal skin both for mouse and guinea pig. The results suggest that atenolol can be pursued further for transdermal system development.