Résumé
The present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formulations. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t50% 2.85 min) compared to the conventional commercial tablet formulation (t50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).
Résumé
The present paper describes a simple isocratic RP-HPLC method for the determination of Amlodipine in tablet dosage form. Best symmetric peak shape was obtained with column Zodiac C18 column (250 mm x 4.6 mm, 5μ) at 245nm with retention time of 5.53min. The mobile phase used was Methanol: Water: Acetonitrile 60:20:20 (v/v/v) with flow rate of 1.0 ml/min. The method for estimation of Amlodipine in tablet dosage form was found to be linear, accurate, precise, sensitive and selective. The linearity range was from 60μg/ml to 210μg/ml. Method was found to be highly sensitive as LOD and LOQ were found to 0.4μg/ml and 1.3μg/ml. The repeatability and reproducibility were within the range i.e. less than 2%. The %recovery values were found to be in the range of 98.82-100.93%. The percentage of assay was calculated for market formulation was 99.19%.
Résumé
The present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formula-tions. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t50% 2.85 min) compared to the conventional commercial tablet formulation (t50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).
Résumé
The present study was done with an aim to standardize the volatile oil obtained from the leaf of Pimenta dioica (Linn.) Merill, belonging to the family Myrtaceae, commonly known as “Allspice”, by HPTLC analysis. The leaves of P. dioica is traditionally being used as a dental analgesic. The present investigation reports the seasonal variation in the content of eugenol, in the leaf volatiles of Pimenta dioica thereby giving insight into the most favorable month for the collection of the drug. Volatile oils are primarily composed of terpenes, the composition of which may alter depending upon the availability of sunlight. The results reveal that the oil collected in April and July showed good content of eugenol.
Résumé
Rhyncosia beddomei Baker commonly known as Adavi-kandi, Vendiaku in Telugu belongs to the family Fabaceae.In the present study, the methanolic extract of Rhyncosia beddomei leaves was evaluated for its hepatoprotective effect against CCl4 induced hepatic injury in rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, triglycerides, bilirubin, total proteins and liver weight were tested in both treated and untreated groups. CCl4 (1ml/kg) enhanced the SGPT, SGOT, ALP, triglycerides, liver weight and reduced total proteins significantly. Treatment with methanolic extract of Rhyncosia beddomei leaves (200mg/kg and 400mg/kg) has brought back the altered levels of altered levels of biochemical markers significantly to the near normal levels in the dose dependant manner. Histopathological studies supported the hepatoprotective activity of Rhyncosia beddomei Baker.
Résumé
Pimenta dioica (Linn.) Merill. Family: Myrtaceae, well known for its berries called Pimento, has been used as an important spice since time immemorial, for its culinary as well as medicinal qualities. It is also known as Allspice due to its intricate aroma which is a medley of aroma from spices such as Clove, Nutmeg and Cinnamon. In India, the leaves of Pimenta are used to flavor rice which gives it a typical aroma. Traditional culinary practice uses the dried berries for marinating meat. Various compounds have been isolated from the plant which belong to categories like phenylpropanoids, tannins, glycosides and essential oil. The present article is a humble effort to study the work done till date on this important spice.
Résumé
Pimenta dioica (Linn.) Merill. Family: Myrtaceae, well known for its berries called Pimento, has been used as an important spice since time immemorial, for its culinary as well as medicinal qualities. It is also known as Allspice due to its intricate aroma which is a medley of aroma from spices such as Clove, Nutmeg and Cinnamon. In India, the leaves of Pimenta are used to flavor rice which gives it a typical aroma. Traditional culinary practice uses the dried berries for marinating meat. Various compounds have been isolated from the plant which belong to categories like phenylpropanoids, tannins, glycosides and essential oil. The present article is a humble effort to study the work done till date on this important spice.
Résumé
Removal of toxic Cr(VI) in aqueous medium was investigated using activated carbon adsorbents prepared from Simarouba glauca seed shells. The pH effect, Cr(VI) concentration, adsorbent dosage and contact time period were studied in batch experiment. The removal of Cr(VI) was in general most effective at pH range 2.0-4.0 and high Cr(VI) concentrations. Activated carbons are prepared at 80050 degrees C temperature. One is non-impregnated and the remaining three are impregnated with zinc chloride in 1:1,1:2,1:3 ratio. Important characteristics of activated carbons are also investigated. The data for all the adsorbents fit well to the Freundlich adsorption isotherm. The removal of Cr(VI) is around 97% was observed with 1:2 impregnated activated carbon at pH 3.0 where as other adsorbents showed much lower activities.