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1.
Braz. j. infect. dis ; 24(1): 81-84, Feb. 2020. graf
Article Dans Anglais | LILACS | ID: biblio-1089333

Résumé

ABSTRACT China's compulsory annual livestock anthrax vaccination policy has remarkably reduced but not completely eradicated human anthrax infections. Herein we describe a sporadic human cutaneous anthrax outbreak involving two cases in 2018 in Shaanxi Province, both involving herdsman who dealt with unvaccinated and potentially sick cattle. Both patients showed Bacillus anthracis-positive blister smear and blood culture. Treatment with penicillin was followed by uneventful recovery for both. The prompt performance of the prophylactic measures successfully interrupted the further transmission of this sporadic human cutaneous anthrax outbreak.


Sujets)
Humains , Mâle , Adulte , Dermatoses bactériennes/anatomopathologie , Maladie du charbon/anatomopathologie , Pénicillines/usage thérapeutique , Bacillus anthracis/isolement et purification , Chine/épidémiologie , Épidémies de maladies , Résultat thérapeutique , Dermatoses bactériennes/traitement médicamenteux , Dermatoses bactériennes/épidémiologie , Maladie du charbon/traitement médicamenteux , Maladie du charbon/épidémiologie , Antibactériens/usage thérapeutique
2.
Braz. j. infect. dis ; 18(1): 110-113, Jan-Feb/2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-703056

Résumé

Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral therapy with short-term heart failure medications and supportive care. Then we review the current literature about interferon induced cardiomyopathy in patients with HCV infection, as well as share our clinical experience in diagnosing and managing this rare complication.


Sujets)
Adulte , Femelle , Humains , Antiviraux/effets indésirables , Cardiomyopathie dilatée/induit chimiquement , Hypothyroïdie/induit chimiquement , Interféron alpha/effets indésirables , Ribavirine/effets indésirables , Antiviraux/administration et posologie , Association de médicaments/effets indésirables , Hépatite C chronique/traitement médicamenteux , Interféron alpha/administration et posologie , Ribavirine/administration et posologie
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