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1.
Chinese Journal of Biochemistry and Molecular Biology ; (12): 980-990, 2023.
Article Dans Chinois | WPRIM | ID: wpr-1015630

Résumé

Cadmium(Cd) stress seriously inhibits the growth and development of plants, and Cd is enriched in the human body along the food chain, causing major risks to human health. Ethylene(ETH) is known for its role as a traditional plant hormone that plays a crucial part in various stress responses. However, the precise mechanisms by which ETH regulates plant tolerance to Cd remain unclear. In this study, we observed that treatment with 3 mg L

2.
China Journal of Orthopaedics and Traumatology ; (12): 495-498, 2023.
Article Dans Chinois | WPRIM | ID: wpr-981721

Résumé

Wallis dynamic stabilization system is a surgical approach in the non-fusion technique of lumbar spine, consisting of interspinous blockers and dacron artificial ligaments that provide stability to the spine while maintaining a degree of motion in the affected segment. Recent studies have demonstrated the significant benefits of Wallis dynamic stabilization system in treating lumbar degenerative diseases. It not only improves clinical symptoms, but also effectively delays complications such as adjacent segmental degeneration. This paper aims to review the literature related to the Wallis dynamic stabilization system and degenerative diseases of the lumbar spine to describe the long-term prognostic effect of this system in the treatment of such diseases. This review provides a theoretical basis and reference for selecting surgical methods to treat degenerative diseases of the lumbar spine.


Sujets)
Humains , Arthrodèse vertébrale/méthodes , Vertèbres lombales/chirurgie , Région lombosacrale , Décompression chirurgicale/méthodes , Dégénérescence de disque intervertébral/chirurgie , Résultat thérapeutique
3.
Journal of Acupuncture and Tuina Science ; (6): 137-140, 2019.
Article Dans Chinois | WPRIM | ID: wpr-756707

Résumé

Objective:To observe the clinical effect of warm needling moxibustion plus acupoint sticking therapy for cervical radiculopathy.Methods:A total of 120 cases were allocated into an observation group,a warm needling group and an acupoint sticking group according to the random number table,with 40 cases in each group.Cases in the observation group received warm needling moxibustion plus acupoint sticking therapy;cases in the warm needling group received the same warm needling moxibustion in the observation group;cases in the acupoint sticking group received the same acupoint sticking therapy in the observation group.The scores of Japanese Orthopaedic Association (JOA) and visual analog scale (VAS) were recorded before and after treatment.Results:The total effective rate was 95.0% in the observation group,versus 77.5% in the warm needling group and 75.0% in the acupoint sticking group (both P<0.05).Inter-group differences in JOA and VAS between the observation group and the other two groups were statistically significant (all P<0.05).Conclusion:Warm needling moxibustion plus acupoint sticking therapy is effective in treating cervical radiculopathy,and it can significantly alleviate pain and enhance clinical efficacy,and thus is worth clinical popularization.

4.
Chinese Journal of Cancer ; (12): 3-11, 2013.
Article Dans Anglais | WPRIM | ID: wpr-295881

Résumé

Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.


Sujets)
Humains , Marqueurs biologiques tumoraux , Métabolisme , Carcinome épidermoïde , Génétique , Métabolisme , Ilots CpG , Génétique , DNA (cytosine-5-)-methyltransferase , Méthylation de l'ADN , Épigenèse génétique , Tumeurs de l'oesophage , Génétique , Métabolisme , Extinction de l'expression des gènes , Gènes suppresseurs de tumeur , Régions promotrices (génétique)
5.
Chinese Journal of Applied Physiology ; (6): 395-398, 2006.
Article Dans Chinois | WPRIM | ID: wpr-253131

Résumé

<p><b>AIM</b>To explore the effect of zinc on vigor of nitric oxide synthase (NOS) and the expression level of neuronal nitric oxide synthase (nNOS) in the hippocampus of acute hypoxic mice and the protective effects of zinc.</p><p><b>METHODS</b>Model of acute hypoxic mice was duplicated, NADPH-d histochemistry and nNOS immunohistochemistry were used to investigate the changes of NOS in different groups.</p><p><b>RESULTS</b>Compared with the NS group, the hypoxia endurance of the zinc group was significantly increased; the number of NOS positive neurons and nNOS positive neurons in hippocampus and CA1 were significantly decreased.</p><p><b>CONCLUSION</b>Zinc might play an important role in decreasing the level of NOS in hippocampus to protect the brain against hypoxic damage.</p>


Sujets)
Animaux , Mâle , Souris , Hippocampe , Métabolisme , Hypoxie , Métabolisme , Lignées consanguines de souris , Nitric oxide synthase , Métabolisme , Nitric oxide synthase type I , Métabolisme , Zinc , Pharmacologie
6.
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 147-150, 2006.
Article Dans Chinois | WPRIM | ID: wpr-343034

Résumé

<p><b>OBJECTIVE</b>To investigate the effect of lithium on hippocampal cholecystokinin (CCK) and neuronal nitric oxide synthase (nNOS) positive neurons and its relationship to the learning and memory ability of lead exposed rats.</p><p><b>METHODS</b>Wistar rats were randomly divided into the control group, the lead group, four lead + LiCl (3, 30, 300, 3,000 mg/kg) groups. Four lead + LiCl groups were fed with food containing 3, 30, 300, 3,000 mg/kg LiCl respectively. The lead + LiCl groups and the lead group were administered with distilled water containing 0.2% PbAc. The body weight was measured and the difference of body development was observed. Y-maze test was used for studying the effects of lead on the learning and the memory ability in rats. ABC immunohistochemistry was used for investigating the changes of CCK positive neurons in hippocampus of lead-exposed rats.</p><p><b>RESULTS</b>Compared with the control group and the lead + LiCl groups, the learning and memory ability of lead exposed rats was significantly higher (P < 0.05). The number of CCK positive neurons in hippocampus lead exposed rats fed with lithium (3, 30, 300 mg/kg) was significantly higher than that in the lead exposed rats (P < 0.05).</p><p><b>CONCLUSION</b>The lead may damage the learning-memory ability of the rats. It might be related to the changes of CCK positive neurons in hippocampus in lead exposed rats. The lithium of the low dose might play an important role in preventing lead-induced damages.</p>


Sujets)
Animaux , Mâle , Rats , Cholécystokinine , Métabolisme , Relation dose-effet des médicaments , Hippocampe , Métabolisme , Immunohistochimie , Plomb , Toxicité , Lithium , Pharmacologie , Apprentissage du labyrinthe , Mémoire , Neurones , Nitric oxide synthase , Métabolisme , Répartition aléatoire , Rat Wistar
7.
National Journal of Andrology ; (12): 655-657, 2005.
Article Dans Chinois | WPRIM | ID: wpr-339458

Résumé

<p><b>OBJECTIVE</b>To explore genital toxicity of depleted uranium (DU) by studying the changes of inducible nitric oxide synthase (iNOS) in the testis of rats instilled with DU particles.</p><p><b>METHODS</b>Wistar rats were exposed to DU by means of different dosages of DU particles intratracheal instillation. The samples of the testis were collected 3 months later, and iNOS mRNA was determined by reverse-transcription PCR (RT-PCR). Semiquantitative analysis of the RT-PCR products was made with a transilluminator.</p><p><b>RESULTS</b>iNOS mRNA was not observed in the control group. Compared with the control, there were significant increases of OD in the PCR products of all the DU groups (P < 0. 05 ); OD rose gradually from the DU 1 mg group to the DU 3 mg group, peaked in the latter, and subsided significantly in the DU 5 mg group (P < 0.05).</p><p><b>CONCLUSION</b>Intratracheal instilled DU particles play a key role in iNOS mRNA expression of the rat testis. The iNOS mRNA expression will weaken when the DU dosage reaches a certain level, which may attribute to the complex of DU's chemical toxicity and radiation effects.</p>


Sujets)
Animaux , Mâle , Rats , Relation dose-effet des médicaments , Relation dose-effet des rayonnements , Expression des gènes , Effets des rayonnements , Nitric oxide synthase type II , Génétique , ARN messager , Génétique , Répartition aléatoire , Rat Wistar , RT-PCR , Testicule , Uranium , Toxicité
8.
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 188-190, 2004.
Article Dans Chinois | WPRIM | ID: wpr-271989

Résumé

<p><b>OBJECTIVE</b>To explore the neuroprotection and the impact on brain development of lithium, the effects of lithium salt on the growth and survival of primary cultured cerebrocortical neurons were studied.</p><p><b>METHODS</b>The technique of primary cultured cerebrocortical neurons of newborn rats with serum-free medium was established, and the growth and survival of neurons treated with different doses of lithium chloride (0.625, 1.250, 2.500, 5.000, 10.000 mmol/L) were observed. The length of neuronal synapse, cell viability by MTT reduction assay were also measured.</p><p><b>RESULTS</b>The neurons were brighter, germinated rapidly, the neuronal synapse lengthened markedly, and the neurons viability was also better after treated with lithium chloride. Among the five doses, 5.000 mmol/L had the best effect [(53.80 +/- 5.84) micro m, P < 0.01].</p><p><b>CONCLUSION</b>Lithium chloride can promote the growth and survival of neurons.</p>


Sujets)
Animaux , Rats , Animaux nouveau-nés , Division cellulaire , Survie cellulaire , Cellules cultivées , Cortex cérébral , Biologie cellulaire , Lithium , Pharmacologie , Neurones , Biologie cellulaire , Neuroprotecteurs , Pharmacologie , Rat Wistar
9.
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 203-206, 2004.
Article Dans Chinois | WPRIM | ID: wpr-271984

Résumé

<p><b>OBJECTIVE</b>To study the effect of taurine on lead-induced damage to the ability of learning and memory.</p><p><b>METHODS</b>Using NADPH-d histochemistry method to study the change of rat NOS positive neurons in hippocampus. Rats in experimental groups were fed with different doses of lead in drinking water (0.011, 0.110 g/L), and different doses of taurine (5, 10 g/kg).</p><p><b>RESULTS</b>Taurine (10 g/kg) could increase the number of NOS positive neurons in CA1 and dentate gyrus subregion in hippocampus of rats exposed to lead. The number of NADPH-d positive neurons in CA1 and dentate gyrus subregion for low lead (0.011 g/L) and high taurine (10 g/kg) group (51.80 +/- 4.68, 47.40 +/- 4.20, respectively) were higher than those in the low lead (0.011 g/L) group (41.20 +/- 5.32, 39.87 +/- 3.81, respectively, P < 0.05).</p><p><b>CONCLUSION</b>Taurine may antagonize lead-induced damage to the ability of learning and memory.</p>


Sujets)
Animaux , Mâle , Rats , Hippocampe , Plomb , Toxicité , Apprentissage , Potentialisation à long terme , Mémoire , Troubles de la mémoire , Neurones , Neuroprotecteurs , Pharmacologie , Nitric oxide synthase , Métabolisme , Rat Wistar , Taurine , Pharmacologie
10.
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 442-444, 2004.
Article Dans Chinois | WPRIM | ID: wpr-258713

Résumé

<p><b>OBJECTIVE</b>To investigate the relationship between the effects of zinc on hippocampal cholecystokinin (CCK) positive neurons and learning and memory ability of lead-exposed rats.</p><p><b>METHODS</b>Thirty-six Wistar rats were divided into control group, lead-exposed group (drunk 6.15 mmol/L of lead solution) and lead-zinc group (drunk 6.15 mmol/L of lead + 3.10 mmol/L of ZnSO(4) solution) randomly. Y-maze test was used to study learning and memory ability in rats; Atomic absorption method was used to determine serum and hippocampal lead content; ABC immunohistochemistry and quantitative graphic analysis were used to investigate the changes of CCK positive neurons in different hippocampal subfields in lead-exposed rats.</p><p><b>RESULTS</b>The learning and memory ability in lead-exposed rats were significantly lower (P < 0.05) while the serum and hippocampal lead content in lead-exposed rat were significantly higher (P < 0.05) than those in control and lead-zinc group. The number and optical density of CCK positive neurons in CA(1) and CA(3) areas of lead-exposed rats were significantly lower (P < 0.05) than those in control and lead-zinc group. No differences in these indexes between the control and lead-zinc group were found (P > 0.05).</p><p><b>CONCLUSION</b>Lead may damage the learning and memory ability and affect the number of CCK positive neurons in lead-exposed rats. Zinc might play an important role in preventing lead-induced damages.</p>


Sujets)
Animaux , Rats , Cholécystokinine , Métabolisme , Hippocampe , Métabolisme , Plomb , Toxicité , Apprentissage du labyrinthe , Mémoire , Neurones , Métabolisme , Rat Wistar , Zinc , Pharmacologie
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