Effect of valsartan on postprandial plasma inflammatory factors in patients with essential hypertension / 中南大学学报(医学版)

OBJECTIVE@#To explore the effect of valsartan on the concentrations of plasma inflammatory factors after a high-fat meal in patients with essential hypertension in very short time.@*METHODS@#Fifty hypertensive patients and 25 healthy controls were studied. Patients randomly accepted lacidipine 4 mg/d (lacidipine group) or valsartan 80 mg/d (valsartan group) for 1 week. The concentrations of plasma lipid profiles, high-sensitivity C-reactive protein (hsCRP) and soluble P-selectin were measured in fasting state and at 4 h after a single high-fat meal in all subjects at baseline and in patients after 1 week.@*RESULTS@#The concentrations of postprandial plasma hsCRP and soluble P-selectin significantly increased after a high-fat meal in patients (P < 0.05), as compared with those at fasting levels, but not in the controls. The postprandial plasma triglyceride concentrations significantly increased in the healthy controls (P < 0.05), but were lower than those in hypertensive patients (P < 0.01). Postprandial change in plasma concentration of triglyceride was significantly correlated with those of log (hsCRP) (r = 0.344)and soluble P-selectin (r = 0.432), respectively (n = 75, both P < 0.01). Lipids profiles did not change significantly after 1 week. There was no significant difference between the fasting and postprandial plasma concentrations of either hsCRP or soluble P-selectin in valsartan group, while the postprandial increments of inflammatory factors were still significant in the lacidipine group.@*CONCLUSION@#High-fat meal can induce postprandial inflammation response in patients with essential hypertension. Valsartan effectively attenuates this postprandial inflammation response within a very short time.

Study on purification process of depsides in Salvia miltiorrhiza with macroporous resin / 中国中药杂志

<p><b>OBJECTIVE</b>To study the technological parameters of the purification process of Depsides in Salvia miltiorrhiza with macroporous resin.</p><p><b>METHOD</b>The adsorptive characteristics and eluting parameters of the process were studied by taking the content of depsides as index.</p><p><b>RESULT</b>85 mL of extractive of depsides (1.25 g x mL(-1)) was purified with a column of macroreticular resin ( Phi30 mm,127 mL) and washed with 4 BV of distilled water, the eluted with 4 BV of 80% ethanol (1% ammonia).</p><p><b>CONCLUSION</b>This process of applying macroporous resin to adsorb and purify depsides in S. miltiorrhiza is feasible.</p>