RÉSUMÉ
Objective To understand the distribution of serum Homocysteine (Hcy)among the middle -aged and the elderly in a refining and chemical company and to provide suggestions for prevention and control of hyperhomocysteinemia (HHcy).Methods A total of 5 113 employees aged over 40 who received annual physical examination in our medical center in 2013 were enrolled in this study.Serum Hcy levels and HHcy positive rate were analyzed by gender and age.The relationship between HHcy and major risk factors of cardiovascular diseases were also analyzed.Results Serum Hcy levels and HHcy positive rate among male were higher than female in each phase of age The difference was statistically significant (P <0.01 ).Within the same gender group,HHcy positive rate increased significantly with age (P <0.01 ).Linear correlation and logistic regression showed that male (OR =3.99,95%CI =3.12 -5.10),age (OR =1.02,95%CI =1.01 -1.02),history of hypertension(OR =2.56,95%CI =2.04 -3.22),systolic pressure(OR =1.01,95%CI =1.01-1.02)and body mass index (OR =1.40,95% CI =1.04 -1.89 )were independent risk factors of HHcy,while creatinine clearance(OR =0.39,95%CI =0.31 -0.49)was protective factor.Conclusion The age,systolic pressure, body mass index and creatinine clearance was related to Hcy levels.