Résumé
In order to clarify the chemical constituents in Qiliqiangxin capsule, a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry (UPLC-Q-TOF/MS(E)) method was established. Forty peaks were identified on line using this method. The herbal sources of these peaks were assigned. The results implied that triterpenoid saponins, flavonoid glycosides, C21-steroids and phenolic acids were included in the main components of Qiliqiangxin capsule. The method is simple and rapid for elucidation of the constituents of Qiliqiangxin capsule and the results are useful for the quality control of Qiliqiangxin capsule.
Sujets)
Capsules , Chromatographie en phase liquide à haute performance , Médicaments issus de plantes chinoises , Chimie , Flavones , Ginsénosides , Hétérosides , Hydroxybenzoates , Plantes médicinales , Chimie , Contrôle de qualité , Saponines , Spectrométrie de masse ESI , Stéroïdes , Spectrométrie de masse en tandem , TriterpènesRésumé
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system, anti-senility, reversing multidrug resistance of tumor cells, adjuvant anti-cancer chemotherapy, promoting peripheral nerve regeneration, et al, are reviewed.