Oncolytic immunotherapies: Opportunities and challenges / 医学研究生学报

Cancer is the first cause of death in China. From traditional treatment to targeted therapy and again to immunotherapy, each step forward has brought us a new hope and some challenges as well. Effective antitumor immunotherapy relies on two aspects, breakdown of immunotolerance and maintenance of system immune homeostasis. Oncolytic viruses (OVs) are capable of selective replication in malignant cells and induction of their lysis and death. With a characterization of OVs, this review introduces the mechanisms of oncolytic immunotherapy and the Results of related studies.