A case-control study on the risk factors of hepatocellular carcinoma in Guizhou Province / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To determine the risk factor of HCC in Guizhou.</p><p><b>METHODS</b>A group case-control study design was conducted between 762 cases and 798 controls in Guizhou province. The main related-factors were analyzed with unconditional logistic regression model and evaluated by odds ratio (OR) and 95% confidence interval (95% CI).</p><p><b>RESULTS</b>There are significant differences between cases and controls in regarding to cigarette smoking 210 (27.6%),non-alcoholic fatty liver disease 336 (44.1%), alcoholic liver disease 245 (32.2%), family history of HCC 141 (16.5%), alcohol consumption 300 (39.4%), HBV infection 436 (57.2%), pickled food 290 (38.1%), and economic status 5 years ago 420 (55.1%) in cases,and cigarette smoking 116 (14.5%),non-alcoholic fatty liver disease 160 (20.1%), alcoholic liver disease 101 (12.7%), family history of HCC 40 (5.0%), alcohol consumption 180 (22.6%), HBV infection 82 (10.3%), pickled food 225 (28.2%), and economic status 5 years ago 647 (81.1%) in controls, with OR of each variable was 3.520, 2.464, 4.330, 2.219, 2.451, 19.245, 6.212, 0.174 respectively, P less than 0.01.</p><p><b>CONCLUSION</b>HBV infection and pickled food were the most common risks for HCC in Guizhou. Alcohol consumption excessively and cigarette smoking may increase the risk too.</p>

Efficacy of Reduced Glutathioue plus Xiangdan Injection for Anti-Tuberculosis Drug-induced Hepatic Lesion / 中国药房

OBJECTIVE:To observe the therapeutic efficacy of reduced glutathioue plus Xiangdan injection for anti-tuberculosis drug-induced hepatic lesion. METHODS:A total of 75 patients with anti-tuberculosis drug-induced hepatic lesion were randomly divided into two groups:38 cases (trial group) were assigned to receive reduced glutathioue (1.2 g) that was added into normal saline(250 mL) by iv gtt q.d plus Xiangdan injection (20 mL) that was added into 10% glucose injection (250 mL) q.d by iv gtt;37 cases(control group)received potassium magnesium injection (20 mL)which was added into 10% glucose injection(250 mL) q.d by iv gtt. After treatment for 4 weeks,the liver function parameters and the total effective rates in two groups were measured. RESULTS:Compared with control group,the liver function had a significantly better improvement in trial group (P