Association of the xeroderma pigmentosum group D DNA repair gene with hepatocellular carcinoma / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To explore the association between polymorphisms in the DNA repair gene, xeroderma pigmentosum group D (XPD), and development of hepatocellular carcinoma (HCC) in the Chinese population by performing a systematic review of the previously published clinical data.</p><p><b>METHOD</b>A comprehensive literature search of the BIOSIS Previews and PubMed databases was carried out to identify all case-control studies of XPD polymorphisms and HCC risk. Meta-analysis was conducted to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) of developing HCC for carriers of the various XPD polymorphisms.</p><p><b>RESULTS</b>Six case-control studies were selected for this meta-analysis, and comprised a total of 3424 HCC cases and 3636 controls. The pooled ORs (95% CIs) of XPD codon 751 and 312 allelomorphs were 1.25 (0.70 to 2.24) and 0.85 (0.58 to 1.25), respectively. Compared with the XPD wild-type homozygote Lys/Lys genotype of codon 751, the pooled OR (95% CI) of Lys/G1n + Gln/Gln genotypes for HCC risk was 1.31 (0.71 to 2.42). Compared with the XPD wild-type homozygote Asp/Asp genotype of codon 312, the pooled OR (95% CI) of Asp/Asn + Asn/Asn genotypes for HCC risk was 1.19 (0.73 to 1.95).</p><p><b>CONCLUSION</b>Polymorphisms in the XPD codons 751 and 312 are not associated with HCC risk in the Chinese population.</p>

Study of the relationship between glutathione S-transferase genetic polymorphisms M1 and T1 and susceptibility to primary liver cancer in Chinese: a meta-analysis / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To study the association of genetic polymorphism of glutathione S-transferase (GSTM1 and GSTT1) with susceptibility to primary liver cancer in Chinese.</p><p><b>METHODS</b>Literature search of the PubMed, Chinese National Knowledge Infrastructure, and ISI Web of Science databases identified 25 relevant case-control studies of glutathione S-transferase genetic polymorphisms and primary liver cancer, representing a total of 2788 cases and 5548 controls. The extracted data was applied to the RevMan v4.2 software for meta-analysis. Data with significant heterogeneity was assessed by the fixed effects model, otherwise a random effects model was applied. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</p><p><b>RESULTS</b>The correlation between the GSTM1 and GSTT1 null genotypes and susceptibility to primary liver cancer showed statistical significance (cases: P = 1.8 * 10(-11) and controls: P = 4.6 * 10(-11); Pearson's Chi-squared test). The OR value for GSTM1 was 1.67 (95% CI: 1.39-2.01) and for GSTT1 was 1.59 (95% CI: 1.26-1.96). In the GSTM1-GSTT1 interaction analysis, both GSTM1 and GSTT1 were null genotypes with OR = 3.34 (95% CI: 2.23-5.00), which was higher than the null genotype for either one of them alone and which indicated higher relative susceptibility. Compared with individuals for whom both GSTM1 and GSTT1 were non-null genotypes, the presence of at least one null genotype showed higher risk of primary liver cancer.</p><p><b>CONCLUSION</b>The null genotypes of glutathione S-transferase genetic polymorphisms GSTM1 and GSTT1 are risk factors for primary liver cancer respectively, and their associated risk is increased when both are present.</p>