Résumé
Objective To determine the clinical value of myocardial performance index (MPI) in the assessment of right ventricular function in the patients with atrial septal defect (ASD). Methods The study included 23 patients with ASD and 81 normal subjects. MPI, defined as the sum of isovolumic relaxation time and isovolumic contraction time derived by ejection time, was measured from tricupid inflow and right ventricular outflow Doppler velocity profiles recorded during routine echocardiography. Results ①The isovolumic relaxation and isovolumic contraction times [respectively ( 74.78 ? 13.86 )ms vs ( 60.93 ? 12.94 )ms, P
Résumé
Objective To evaluate changes of RV volume and function in patients with ASD after transcatheter closure of ASD by three-dimensional echocardiography. Methods In 58 patients with ASD (24 men, 34 women; mean age 28.9?17.1, range 4 to 67 years), 23 patients (11 men, 12 women; mean age 25.7?13.3, range 6 to 57 years) were diagnosed as secundum ASD [the stretched diameters of ASD were from 9 to 36 (25.1?7.5) mm], and had successfully received Amplatzer septal occluder (ASO, the sizes of ASO ranged from 11 to 40 mm ). 32 healthy people (18 men, 14 women; mean age 24.8?12.0, range 4 to 45) were matched interms of age and sex as the control group. Three-dimensional images were acquired by HP-SONOS 5500 cardiac scanner (Hewlett-Packard Company, Andover, Mass) and were reconstructed by Tom-Tec EchoView 4.2 (TomTec Imaging Systems, GmbH) to calculate right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV) and right ventricular ejection fraction (RVEF). RVEDV, RVESV and RVEF were measured at 3 days, 1 and 3 months after the procedure. Results The RVEDV and RVESV [(101.74?25.17) mL vs (59.65?15.00) mL, P
Résumé
Objectives:The present study in vestigated the presence and significance of serum antibody against human myocardial mitochondria in patients with virus myocarditis (VMC) and dilated cardiomyopathy (DCM). Methods:The human myocardial mitochondtia were used as antigen to detect serum autoantibody by immuno-dot blot in 29 VMC patients,24 DCM patients,33 patients with other cardiac (OCD) and 20 healthy blood donor (HBD).The antigen molecular weight was detected by Western blot. Results:①Positive autoantibody against human myocardial mitochordria was found in 41.4% in VMC and 41.7% in DCM patients,which were much higher than 6.1% in OCD or 0% in HBD patients.②Cardiac troponin T was elevated in 43.8% of autoantibody-positive VMC and DCM patients,which was much higher than 12.0% in autoantibody-negative VMC and DCM patients (p＜0.05).③The antigen molecular weight of human myocardial mitochondria was 30KD. Conclusions:①The presence of autoantibody against supports that concept that is responsible for the development of VMC and DCM.Autoantibody is one of the factors that give rise to cardiac injury.The antibody detection may serve as a diagnostic index for VMC and DCM.②The specific antigen is probably human myocardial adenine nucleotide translocator.