Progression of the FLT3 Inhibitor in acute myeloid leukemia / 白血病·淋巴瘤

FLT3, a tyrosine kinase receptor, is the most common mutation in AML and has two classes of mutations: internal tandem duplications in the juxtamembrane domain (FLT3-ITDs) and point mutations in the tyrosine kinase domain (FLT3-TKDs). AML patients with FLT3 mutations tend to have a poor prognosis. As an independent factor, the presences of FLT3 mutations play an important role in the origin and development of AML and have prognostic value. Molecular targeted therapy represents a novel and popular therapeutic approach in the world. In this review, we explain clinical value of the FLT3 mutations, mechanism and research progression of the FLT3 inhibitor;and discuss difficulties and perspectives in the research of the FLT3 inhibitor.

PIG7 gene and human diseases / 基础医学与临床

Apoptosis induced byP53 gene is one of the most important mechanisms of signal integration in cells,which identify the cell injury and start downstream apoptotic signals.PIG7 gene is induced byP53 and correlates with metabolism,inflammation and tumor occurence.Here we reviewed the recent findings in the molecular biology ofPIG7 gene and the correlation with human diseases.