Résumé
OBJECTIVE:To arouse great attention in the circle of medicine to the presupposition of canceling drug price addition in hospitals.METHODS:The causes,effects and drawbacks of drug price addition in hospital were introduced;The aim,possibility and feasibility of canceling drug price addition were pondered over;The possible ways for the compensation for revenue losses in hospital due to the canceling of drug price addition were proposed;The possible changes in drug prices and hospital pharmacy after the canceling of drug price addition were predicted and the corresponding developmental strategy on hospital pharmacy were put forward.RESUTLS&CONCLUSION:It is possible and feasible to cancel hospital drug price addition,which will bring about significant influences(both positive and negative)on drug prices and hospital pharmacy once being put into practice,to which great attention should be paid.
Résumé
【Objective】To determine the content and dissolution of two imported levothyroxine sodium tablets.【Method】The content of levothyroxine sodium was assayed on a Hypersil BDS C18 column with a mobile phase consisting of methanol-0.85% phosphoric acid (60∶40) at a flow rate of 1.5 mL/min and detected at 225 nm.The study on dissolution was conducted according to the method Ⅱ of dissolution apparatus in USP(23).【Results】The average content of two formulations was 107.74% and 99.72%,respectively.The value of T50,Td and m of two tablets differed significantly (P<0.01).【Conclusion】There was a significant dissolution difference between two levothyroxine sodium tablets.
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OBJECTIVE:To discuss the existence and possibility of development of hospital preparations in new situation in China.METHODS:To describe the basis and problems for existence and development of hospital preparations in new situation in China.RESULTS:There are necessity of existence and possibility of development of hospital preparations,however,the hospital preparation should be regulated in construction of assortment,decreased in quantity and reduced in scale.CONCLUSI_ON:As long as the development strategy for hospital preparations,controlling scale,ensuring quality,creating unique features and developing new drugs,is persisted,the prospect of hospital preparation will certainly be bright.
Résumé
The effects of Panax notoginseng saponins (PNS) and verapamil(Ver)on hemo-dynamics of internal carotid artery and superior mesenteric artery were determined and compared in anesthetized Sprague ~ Dawley strain rats. PNS 30-150 mg ? kg-1 iv was shown to reduce the mean blood pressure, internal carotid arterial resistance and superior mesenteric arterial resistance by 11 % ~19%, 14%~27%,23%~ 39%respectively. Meanwhile, the mesenteric ar-terial blood flow increased.by 16%~51%. Ver showed similar reflects as PNS. The results indicated that the vasodilation effects of PNS and Ver are vascular selective, that is PNS and Ver are more potent in dilating the mesenteric artery than the internal carotid artery.