1.
Acta Pharmaceutica Sinica
;
(12): 70-4, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-382378
Résumé
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.