[Prognostic factors of advanced stage non-small-cell lung cancer]

Background: Lung cancer is the main cause of death from cancer in the world. The 5-year survival is about 15%. Despite the progress of medicine the mortality rate decreased only marginally. This poor prognosis is due to late diagnosis

Aim: To evaluate overall survival and prognostic factors in patients locally advanced or metastatic non small cell lung cancer [NSCLC]

Methods: Retrospective study including 180 patients with non-small cell lung cancer hospitalized in the department of Charles Nicolle Hospital of Tunis between January 2007 and December 2014

Results: The mean age was 61.5 years with a male predominance [93.3%]. The median overall survival was 6 months. The poor prognostic factors were the performans status [PS] and early delays of management [<30 days]. The factors that improve survival were surgical treatment and delays of management more than 45 days

Conclusion: The prognostic factors in locally advanced and metastatic NSLC in our patient were: PS, management delay and treatment. These factors should be considered in management of patient with advanced stage NSCLC

[Predictive factors of the outcome of smoking cessation among Tunisian women]

Background: The spread of smoking among women in Tunisia has reached alarming proportions because of increasing smoker rate, the younger age of smoking initiation and therefore its duration

Aim: Identify predictors of success or failure of smoking cessation, Methods: we conducted a retrospective study [January 2008-June 2011], including 101 female smokers [19.8%] among 510 smokers of both sexes undergoing smoking cessation interventions. Univariate and multivariate analysis between groups of smokers who succeeded and who failed smoking cessation was performed

Results: Average age of our patients was 44 years. The overall success rate at 6 months and 1 year were respectively 24.7 and 18.8%. In univariate analysis, a statistically significant difference in terms of successful weaning was observed in smokers who had a late age of smoking onset [after 20 years] [p = 0.03], respiratory or cardiovascular comorbidities associated [p = 0.03] and good adhesion to the consultation [p = 0.02]. In multivariate analysis only the presence of a tobacco-related disease [OR: 4.43, 95% CI [1.29- 15.17], p = 0.01] and adherence to the consultation [OR 5.02 95% CI [1.29 -19.39], p = 0.01] were significantly associated with a good prognosis for successful weaning at 6 months and one year. A possible but not significantly associated with age of smoking initiation was observed [OR = 0.3 95% CI [0.08 - 1.07], p = 0.06]

Conclusion: Beyond validated smoking cessation and prolonged follow-up, a differential approach, taking into account women specificities, would increase the chances of quitting smoking

[Management of non small cell lung cancer]

The broncopulmonary cancer is a major problem of public health whose diagnosis is most of the time unfavorable. For a long time, strategies of management of cancer have not taken into consideration much the histological type and few authors have studied the implication of histological type of cancer on the future of patients having cancer. Taking into account the results of recent studies, we propose to review the recent epidemiological and biological aspects of bronchial cancers and then to study the impact on the therapeutic strategy. Review of literature. The scientific progress and the discovery of new mechanisms of carcinogenesis considerably enlarge the therapeutic potential targets and enable to adopt a more specific approach of the cancer cell. Despite the progress observed in thoracic cancerology, the benefits concerning survival remain modest. The oncoming of new molecules specifically targeting a stage of oncogenesis enables a better therapeutic selectivity and a lesser toxicity