Study on anti-gastric cancer mechanism of Wisteria sinensis tumor based on network pharmacology, molecular docking technology and experimental verification / 中国药理学通报

To investigate the pharmacological mechanism of Wisteria sinensis tumor in the treatment of gastric cancer, using a network pharmacology and molecular docking approach, with verification of the results by experiments. Methods The main active components and corresponding targets of Wisteria sinensis tumor monocytogenes, as well as the disease targets of gastric cancer, were obtained through the network pharmacology database. The Venny 2.1.0 platform was used to take the intersection of drug and disease. The String database was used to construct target protein interaction(PPI)network for common targets, and Metascape database was used to analyze GO function enrichment KEGG pathway enrichment of related targets. The interactive network of "component-target-pathway" of Wisteria sinensis tumor on gastric cancer was constructed by Cytoscape3.7.2 software. The molecular docking of the key targets and active compunds was carried out by using Autodock Vina software. The effect of Wisteria sinensis tumor on gastric cancer was verified by in vitro cell tests. Results A total of 8 main active components, 290 drug targets and 251 gastric cancer-related targets were screened out. A total of 19 targets intersected between with drug and diseases. Seven pathways were involved in the treatment of gastric cancer by Wisteria sinensis tumor. The results of molecular docking showed that the main active components of Wisteria sinensis tumor had good binding ability with the key targets of gastric cancer. The results of in vitro experiments confirmed that, the formononetin from Wisteria sinensis tumor had certain activity on gastric cancer cells, and the formononetin could also induce apoptosis of gastric cancer SGC-7901 cells and increase the level of intracellular calcium ion. Conclusions This study preliminarily reveals the potential components and regulatory network of Wisteria sinensis tumor monocytogenes acting on gastric cancer clarified that Wisteria sinensis tumor monocytogenes has antitumor effect, and may be related to inducing apoptosis of gastric cancer SGC-7901 cells, and it provides references for the future research and clinical application.

Irritable bowel syndrome in China: a review on the epidemiology, diagnosis, and management / 中华医学杂志(英文版)

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease worldwide. Current guidelines of IBS are mostly based on the western populations and expected to vary in different communities. China has a large population and a vast literature is available on IBS. Due to linguistic variations in the literature, the studies are not widely known and their conclusions thus remain largely obscured to the western medical literature. In this article, we reviewed the published literatures on the investigations of IBS epidemiology, diagnosis, and management in the Chinese population and emphasized the different findings gleaned from the western publications. The detailed literature review will benefit understanding of and promote future study on IBS.

Chemical constituents from ethyl acetate extraction of Prunus mume / 中国中药杂志

Eight compounds were isolated from the ethyl acetate extraction of Prunus mume by column chromatography. On the basis of physicochemical properties and spectrum analysis, these compounds were identified as isoquercitrin-6″-O-benzoate(1), pinoresinol(2), naringin(3), ethyl-β-D-glucopyranoside(4), astragalin(5), quercetin(6), hypericin(7), and rutin(8). Among them, compound 1 was a new natural product, and compounds 2-5 were isolated from this plant for the first time. In vitro study, compounds 1, 3, 5-8 could significantly increase the cell survival ratio.

Effect of Sensomotor Insole on Gait and Energy Expenditure for Children with Cerebral Palsy / 中国康复理论与实践

Objective:To evaluate the effects of sensomotor insole (SMI) on gait and energy expenditure in children with spastic cerebral palsy during walking. Methods:From December, 2014 to March, 2016, 42 children with spastic cerebral palsy aged three to 15 years were recruited. Their gait parameters and energy expenditure of six minute walking were measured under two test conditions: walking with shoes and walking with shoes and SMI. Results:After wearing SMI, the walking distance, speed, left step length and right step length were all greater (t = -6.022~-4.331, Z= -4.814~-4.183, P < 0.001), the both feet single limb support was shorter (t = 2.954, P < 0.05), and the energy expenditure was higher than before (t = -2.358, P < 0.05). Conclusion:SMI as a sort of orthopedic insole, could improve the gait parameters of children with cerebral palsy immediately after wearing it, and increase the energy expenditure slightly.

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia / 中华医学杂志(英文版)

<p><b>Background</b>Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD.</p><p><b>Methods</b>The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared.</p><p><b>Results</b>(1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo.</p><p><b>Conclusion</b>Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo.</p><p><b>Trial Registration</b>https://clinicaltrials.gov/, NCT02460601.</p>

Chemical constituents from fresh tubers of Dioscorea bulbifera / 中国中药杂志

Eighteen compounds were isolated from the 95% ethanol extract of fresh tubers of Dioscorea bulbifera by column chromatography over silica gel,Sephadex LH-20, and ODS. Their structures were elucidated by spectroscopic data analysis as 6-hydroxy-2,10,10-trimethoxy-anthracen-9-one(1), diosgenin (2), stigmasterol(3), 3, 7-dimethoxy-5, 3', 4'-trihydroxyflavone(4), 2, 7-dihydroxy-3, 4-dimethoxyphenanthrene(5), 3, 7-dihydroxy-2, 4-dimethoxy phenanthrene(6), 2, 7-dihydroxy-4-methoxyphenanthrene (7), 2, 7-dihydroxy-3, 4-dimethoxy-9, 10-dihydroxy phenanthrene(8), azelaic acid (9), 8-epidiosbulbin E acetate (10), 1, 7-bis-(4-hydroxyphenyl)-4E, 6E-heptadien-3-one(11), diosbulbin B(12), pentacosanoic acid 2', 3'-dihydroxypropyl ester(13), 2, 7-dihydroxy-4-methoxy-9, 10-dihydroxy-phenanthrene (14), 1, 7-bis-(4-hydroxyphenyl)-1E, 4E, 6E-heptatrien-3-one (15), 6-ethoxy-1H-pyrimidine-2, 4-dione (16), 3, 5, 4'-trihydroxy-bibenzyl (17), and diosbulbin F (18). Compound 1 is a new compound, and compounds 7, 9, 13, and 16 were isolated from this plant for the first time.

Radiologic observation of the blood supply changes around the knee with osteoarthritis / 中国骨伤

<p><b>OBJECTIVE</b>To compare blood supply changes around the knee joint between normal and osteoarthritis knee.</p><p><b>METHODS</b>From June 2014 to June 2015, 30 patients with knee osteoarthritis and 30 healthy adults were recruited. In osteoarthritis group, there were 9 males and 21 females, with a mean age of (65.967±7.132) years old(ranged, 53 to 82 years old), and the mean arterial pressure was(93.462±7.633) mmHg. In control group, there were 9 males and 21 females, with a mean age of (62.867±6.356) years old(ranged, 50 to 75 years old), and the mean arterial pressure was (92.122±9.675) mmHg. Inspection methods included color ultrasonic and computed tomography angiography of lower limbs. The patients were observed with: (1)collateral circulation; (2)artery circuity; (3)artery malformation; (4)artery stenosis; (5)arterial wall plaque formation. Stenosis was divided into 5 levels: level 1 as no narrow, level 2 as mild stenosis (1% to 49%), level 3 as moderate stenosis (50% to 70%), level 4 as severe stenosis (70% to 99%), level 5 as total obstruction. Diameter and blood flow dynamics of popliteal artery, pretibial artery, and posterior tibia artery in two groups were measured and compared.</p><p><b>RESULTS</b>The study was accomplished with complete data collection, none of the patients was eliminated, and there were no loss of follow up. There were 3 cases in OA group and 4 cases in control group with the formation of collateral circulation, and the difference had no statistically significance. There was none in OA group and 2 in control group with the formation of artery circuity, and the difference had no statistically significance. There were no cases in both groups with artery malformation. In OA group, there was mild in 14 cases, moderate in 7 cases, severe in 9 cases. In control group, there was no arterial stenosis in 9 cases, mild in 10 cases, moderate in 6 cases, severe in 4 cases, total obstruction in 1 case. The difference between two groups was statistically significant; artery stenosis in OA group was more severe than that of the control group. Artery plaque formed in 30 cases in OA group and in 20 cases in control group. The difference between two groups was statistically significant; the rate of artery plaque formation in OA group was obviously higher than that of control group. In OA group, plaque calcification rate was 100% while 63% in control group. Difference of pretibial artery diameter was statistically significant, pretibial artery diameter is larger in OA group. Difference of popliteal artery flow velocity was statistically significant; velocity was faster in OA group. Difference of the posterior tibial artery flow velocity was statistically significant; velocity was faster in OA group. The differences of the three arteries had no statistical significances in related to arterial flow.</p><p><b>CONCLUSIONS</b>Local artery system changes with the onset of knee joint osteoarthritis. Main pathological changesof local blood vessels were stenosis and plaque formation, but the amount of local artery blood flow was roughly the same as the control group. Possible mechanism is that the local artery stenosis speed up the artery blood flow velocity, resulting local perfusion. The local tissue ischemia and hypoxia caused a series of pathological changes. It is better to improve local vascular lesions than to accelerate the blood flow velocity in clinical treatment. Further more, interventional therapy for vascular pathology will be a new trend of osteoarthritis treatment.</p>

Total hip arthroplasty for patients with failed internal fixation of acetabular fractures / 中国骨伤

<p><b>OBJECTIVE</b>To observe the clinical result and healing of meniscal suture under arthroscopy for the treatment of the middle aged patients with meniscal injury.</p><p><b>METHODS</b>From March 2014 to January 2015, 40 middle-aged patients included in the standard with injury of meniscus, which were repaired by meniscal suture technique under arthroscopy, involving 24 males and 16 females with an average age of (52.65±3.63) years ranging from 50 to 60 years; 28 cases were on left knee, 12 cases were on right knee. Average flexion angle averaged (117.50±7.16) ° ranging from 110° to 130°. Lysholm knee score averaged 54.30±14.72 ranging from 23 to 71; IKDC score averaged 50.65±15.95 ranging from 18 to 78; the WOMAC score averaged 23.80±19.39 ranging from 2 to 75. All-inside meniscus suture under arthroscopy was performed.</p><p><b>RESULTS</b>All operations were successful without serious complications. Postoperative follow-up was 6 to 12 months, none of the patients lost to follow-up. All patients maintain a category 5 degree muscle strength, normal knee joint mobility, can completely straight and completely buckling. Average flexion angle was (125.00±5.13) ° (110° to 130°) (=3.47,=0.003). Final Lysholm scale, IKDC scores and WOMAC scores averaged 79.50±8.70 (=7.790,=0.000), 79.40±10.40 (=8.431,=0.000), 8.15±6.77 (=3.988,=0.001) separately. Follow-up MRI showed that meniscus healed in 4 cases, partially healed in 22 cases, haven't healed in 14 cases. Failure rate of small lesion was 27.3%(6/22), and failure rate of large lesion was 44.4%(8/18).</p><p><b>CONCLUSIONS</b>Clinical effect of meniscal suture under arthroscopy for the treatment of the middle aged is good. The failing rate was 35% because of healing ability is poor in middle-aged adults. Failure rate of large lesion was higher than that of small lesion.</p>

Arthroscopic reduction and utilization of Suture Bridge tech reconstructing footprint area structure for the treatment of anterior cruciate ligament avulsion fracture / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the preliminary curative effect of arthroscopic reduction and utilization of Suture Bridge tech reconstructing footprint area structure for anterior cruciate ligament avulsion fracture.</p><p><b>METHODS</b>From March 2010 to September 2012, 6 patients suffered anterior cruciate ligament avulsion fracture were treated with arthroscopic Suture bridge fixation for anterior cruciate ligament tibial side footprint reconstruction. There were 2 males and 4 females, ranging in age from 14 to 52 years old. There were 2 cases of type III and 4 cases of type IV displaced fractures classified by Meyers-McKeever-Zaricznyj. Preoperative ADT and Lachman tests were positive.</p><p><b>RESULTS</b>All the patients was follow up more than 2 years. Postoperative ADT and Lachman tests were negative without limitation of knee extension. Postoperative X ray and MRI showed that displaced fracture with a good reduction and union, recovered normal shapeness of ACL. The postoperative Lysholm and IKDC scores at different time points(3 months, 1 year, 2 years after operation) improved significantly comparing with preoperative, and the differences were statistically significant (<0.01).</p><p><b>CONCLUSIONS</b>Suture Bridge tech reconstructing footprint area structure for ACL avulsion fracture is an effective and safe method, especially for adolescent patients with unclosed epiphysis and comminuted avulsion fracture.</p>

Arthroscopic rotator cuff repair using a suture-bridge technique in late middle-aged adults / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the clinical results after arthroscopic rotator cuff repair using a suture-bridge technique in late middle-aged adults.</p><p><b>METHODS</b>A retrospective analysis of 30 patients with rotator cuff tears, who were treated consecutively between December 2012 and December 2013 at our clinic, was carried out to evaluate the outcome of arthroscopic suture-bridge technique. The visual analogue scale (VAS), the range of motion (ROM), the rating scale of the University of California at Los Angeles (UCLA), and the shoulder index of the American Shoulder and Elbow Surgeons (ASES) were determined as the evaluation criteria.</p><p><b>RESULTS</b>The mean follow-up period was 13 months. The follow-up rate was 100%. The study included 0 small, 16 medium, 12 large and 2 massive rotator cuff tears. At the latest follow-up, the VAS score decreased significantly from preoperative 6.3±3.2 to 0.8±1.4 at rest,and from preoperative 7.7±2.1 to 1.7±1.6 during motion. The UCLA score improved significantly from 15.1±4.6 preoperatively to 31.2±5.0 at follow-up. The ASES shoulder index improved significantly from 30.2±16.0 preoperatively to 80.4±13.0 at follow-up. The ROM improved significantly. The satisfactory rate was 94%. There were no complications.</p><p><b>CONCLUSION</b>The results of this study indicate that the arthroscopic suture-bridge technique is an effective and reliable treatment for patients with rotator cuff tear in late middle-aged adults.</p>

Arthroscopic partial meniscectomy for medial meniscal tear in late middle-aged adults / 中国骨伤

<p><b>OBJECTIVE</b>To study the results of arthroscopic partial meniscectomy for medial meniscal tear in late middle-aged adults.</p><p><b>METHODS</b>From October 2010 to October 2012,49 patients meeting inclusion criteria were treated with arthroscopic partial meniscectomy for medial meniscal tear. There were 31 males and 18 females,with an average age of (55.3±2.8) years old. There were 22 left knees and 27 right knees. The average flexion angle was (116.01±12.03)°. The pre-operative HSS Knee Score was 48.73±8.43, and the Lysholm score was 63.95±5.45. The patients were followed up and evaluated. All the patients received a standard surgery, in which the torn tissue was removed, and the anterior part of the meniscus was left in situ.</p><p><b>RESULTS</b>All the surgeries were successful with no serious complications. All the patients were followed up,and the duration ranged from 12 to 36 months. All the patients had 5 degrees of muscle strength. The average flexion angle was (136.77±18.56)°. There was significant difference between the two angles before operation and after operation. The pre-operative HSS Knee Score was 90.17±4.10, and the Lysholm score was 87.84±5.16. Statistically, the difference between preoperative score and the postoperative score was significant.</p><p><b>CONCLUSION</b>Arthroscopic partial meniscectomy is a good option for medial meniscal tear in late middle-aged adults. Operative indication is crucial and the excellent surgical technique is also critical for the good clinical outcome. All the patients could get good clinical results, although there are some patients with motion restrictions in the early stage after operation.</p>

Arthroscopic anterior cruciate ligament reconstruction with remnant preserving technique / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the clinical outcome of arthroscopic reconstruction of anterior cruciate ligament (ACL) with remnant preserving technique.</p><p><b>METHODS</b>From May 2008 to October 2010,68 patients with ACL deficiency (33 males and 35 females, with an average age of 25.8 years, ranged from 17 to 43 years) were treated with arthroscopy. The average duration of the disease was (4.5 +/- 1.1) months. The pivot shift test showed positive results in 55 cases, Lachman test showed positive results in 68 cases, and the ADT (anterior drawer test) showed positive results in 68 cases. The anterior transition of the tibia measured by KT2000 instrument was (7.2 +/- 2.3) mm (5 to 9 mm) more than that of the opposite knee. The average Lysholm score was 55.7 +/- 5.4 (45 to 67). The average Tegner activity scores was 3.1 +/- 0.6 (2 to 4). The tibial tunnels and femoral tunnels were drilled in the middle of the footprint of the ACL, and the graft was wrapped by the remnant. Grafts were fixed with cross pin at the femoral side and with biodegradable interference screw at the tibial side. Postoperative symptoms and signs were observed in the follow-up duration. The anterior transition of the tibia was measured by KT2000, the Lysholm and Tegner scores were used to evaluate knee functions.</p><p><b>RESULTS</b>All the patients were followed up, and the duration ranged from 24 to 42 months, with a mean of (31.5 +/- 2.4) months. At the latest follow-up, there was no patients had positive result by civot shift test, while the Lachman test showed results of negative or positive of grade I, and the ADT test showed results of negative or positive of grade I or II. The anterior transition of the tibia measured by KT2000 instrument decreased to (1.9 +/- 0.7) mm (0 to 3 mm) more than that of the opposite knee (t = 21.15, P = 0.000 1). The postoperative Lysholm score 86.0 +/- 5.1(81 to 97) and Tegner score 7.8 +/- 0.3 (6 to 9) all increased compared with preoperative 55.7 +/- 5.4 and 3.1 +/- 0.6 (t = 18.55, P = 0.001 0; t = 9.11, P = 0.000 5). According to Lysholm score, excellent results were obtained in 55 cases, good in 10, poor in 3 and no bad results.</p><p><b>CONCLUSION</b>The ACL remnant provide vascular and nerve supply for the graft, promoting union and remodeling of grafts.</p>

Combined closing-wedge high tibial osteotomy with arthroscopy for varus knee and medial compartment osteoarthritis: clinical results at a minimum follow-up for five years / 中国骨伤

<p><b>OBJECTIVE</b>To study the results of closing-wedge high tibial osteotomy and arthroscopy for the treatment of medial compartment osteoarthritis of the knee.</p><p><b>METHODS</b>From October 2005 to June 2007, 25 patients met with our inclusion criteria. All the patients with medial compartment knee osteoarthritis were treated with arthroscopy and closing-wedge high tibial osteotomy. There were 11 males and 14 females,with a mean age of 53 years old. The pre-operative HSS knee score was 67.6 +/- 2.8, FTA was (185.54 +/- 1.11) degrees, and aLPTA was (96.54 +/- 0.52) degrees in average. The patients were followed up and evaluated according to HSS knee score. The efficacy of the osteotomy was evaluated by FTA and aLPTA.</p><p><b>RESULTS</b>All surgeries were successful without serious complication. All the patients were followed up, and the duration ranged from 5 to 7 years. The HSS was 85.5 +/- 3.7 at the 1st year and 80.3 +/- 5.4 at the latest follow-up. There was significant difference between every two scores of before operation and the two after operation (t = -33.135, P = 0.000; t = -13.215, P = 0.000). The FTA was (173.65 +/- 0.92) degrees at the 1st year and (174.34 +/- 0.53) degrees at the latest follow-up. There was significant difference between every two angles of before operation and after operation (t = 28.739, P = 0.000; t = 2.331, P = 0.048). The aLPTA was (87.32 +/- 0.33) degrees at the 1st year and (87.67 +/- 2.82) degrees at the latest follow-up. There was significant difference between every two angles of before operation and after operation (t = 37.264, P = 0.000; t = 2.469, P = 0.039).</p><p><b>CONCLUSION</b>Indication is important and good surgical technique is critical for good clinical outcome. A detailed plan before operation is essential for the operation. Arthroscopy is helpful for treating the intra-articular pathology. The osteoarthritis is still in progress but in a slow mode. The combined method of arthroscopy and closing-wedge high tibial osteotomy is a reliable way for medial compartment osteoarthritis of the knee.</p>

Clinical results of anatomical reconstruction of the lateral ligaments for chronic ankle instability / 中国骨伤

<p><b>OBJECTIVE</b>To investigate the clinical and radiological results of lateral stabilization with reconstruction of the lateral ligaments for the treatment of chronic lateral instability of the ankle.</p><p><b>METHODS</b>From September 2005 to March 2010, 29 patients with chronic lateral instability of the ankle were reviewed. There were 24 males and 5 females with an average age of 24 years (15 to 35 years). The duration of the disease ranged from 7 to 10 years, averaged 10 months. The main symptom was repeated ankle sprain. During physical examination, ankle varus and the anterior talar transition were conducted. There was (12.5 +/- 3.2) degrees more inversion activity than the contralateral ankle. Arthroscopy was performed for the chondral injury, and anatomic reconstruction of the lateral ligament with an autologous gracilis tendon graft was performed for lateral instability of the ankle. Clinical and radiological evaluations were performed before surgery and at the most recent follow-up.</p><p><b>RESULTS</b>All the patients with successful surgery, there was no fracture or infection. All the patients were followed up,and the duration ranged from 16 to 60 months, with an average of 28 months. There was no ankle instability or limited mobility of the 29 cases at the latest follow-up. According to the American Orthopedic Foot and Ankle Society ankle-hind foot scale, the mean score was 48.0 +/- 6.7 before surgery and 92.8 +/- 6.2 at the most recent follow-up (P = 0.010). The talar tilt angles on standard stress radiography were (12.5 +/- 3.2) degrees before surgery and (2.5 +/- 0.8) degrees at the most recent follow-up (P = 0.012). The mean distance of anterior talar translation was (16.3 +/- 4.0) mm before surgery and (3.5 +/- 0.8) mm at the most recent follow-up (P = 0.002). There were no severe complications, the results were satisfactory.</p><p><b>CONCLUSION</b>Anatomical reconstruction of the lateral ligament with autologous gracilis tendon graft for the treatment of chronic lateral instability of the ankle can be recommended.</p>

Effect of Panax Notoginseng Saponins on autograft tendon healing in bone tunnel: interface histological characteristics / 中国骨伤

<p><b>OBJECTIVE</b>To investigate the effect of Panax Notoginseng Saponins (PNS) on tendon healing in bone tunnel.</p><p><b>METHODS</b>The experiment was performed in the animal laboratory, Wangjing hospital from April to August, 2010. All the experiment procedures were accorded with the animal ethical requirements. Twenty New Zealand rabbits were randomly divided into blank control group and PNS group with 10 animals in each group. Anterior cruciate ligament reconstruction with toe extensor tendon was done in knee joints of rabbits by suspend fixation model. PNS was injected in bone tunnel of rabbits in PNS group, and nothing was given to blank group. Specimens were collected at 4 and 8 weeks after surgery. Sections were stained with HE stain to observe the changes of interface tissue between bone tunnel and tendon graft. Interface types were classified according to Yamakado method.</p><p><b>RESULTS</b>At 4 weeks after surgery, the interface was filled with connective tissue in both group, while at 8 weeks, there was not obvious gap between bone and tendon graft in both groups under macrography. Under microscope, there were more fibroblast in the PNS group. There was larger new bone formation area in PNS group. The classification on the Yamakado type was significantly different between two group (P < 0.05).</p><p><b>CONCLUSION</b>PNS can enhance tendon-bone healing in bone tunnel, and promote the connection between tendon and bone. The study lacks quantitative analysis of those criteria, and the mechanics of the promotion of tendon-bone healing has not been totally clear.</p>

Treatment of primary frozen shoulder with manipulation under anesthesia combined with arthroscopy / 中国骨伤

<p><b>OBJECTIVE</b>To study the feasibility and effectiveness of manipulation under anesthsia combined with arthroscopy for the treatment of primary frozen shoulder.</p><p><b>METHODS</b>Thirty-four patients with primary frozen shoulder were treated from January 2006 to March 2009, including 20 males and 14 females with an average age of (56 +/- 3.6) years(ranged from 43 to 62 years). The course of the disease ranged from 9 to 13 months, with a mean time of 11.3 months. All the patient were treated with manipulation under anesthsia combined with arthroscopy. The synovitis of the biceps tendon and the rotator interval was thermo-coagulated, and limited synoviectomy was performed. Subacromial bursoscopy was applied to the patients after glenohumeral arthroscopy. Secondly radiofrequency electrode was used to coagulate bleeding and manipulative relax was performed. All the patients started active and passive postoperative rehabilitation from 1st day after treatment and were followed up for an average of 18.9 months (ranged from 13 to 32 months). The range of motion (ROM) of shoulder joint and feeling of pain calculated by Constant score system were compared before and after the operation.</p><p><b>RESULTS</b>The post-operative feeling of pain according to Constant score system at 12 months after operation(total 15 points) was (13 +/- 1.58), which was different from that of pre-operative score of (5 +/- 2.60) (P < 0.01). As compared with pre-operative conditions, the motion of shoulder revealed significant improvement at different postoperative stages (P < 0.05). The total post-operative score according to Constant score system at 12 months after operation was (86 +/- 11.20), which was higher than that of pre-operative score of (27 +/- 2.40) (P < 0.01).</p><p><b>CONCLUSION</b>Manipulation under anesthsia combined with arthroscopy is an effective, optimal, minimal invasive management with high clinical value for primary frozen shoulder.</p>

Current research of the excessive lateral pressure syndrome of patellofemoral joint / 中国骨伤

As modern medicine getting deeply to understand ever-detailed anatomy,structure and animal mechanics of the patellofemoral joint, excessive lateral pressure syndrome, a very common patellofemoral disorder, has been reacquainted by the clinicians. On account to the complexity and variety of the etiology and the mechanism of the pain, still, there are many difficulties and arguments on the exact description of the clinical symptoms and the establishment of a universally accepted diagnostic criteria. Accurately grasping different causes, pathomechanisms and developmental stages of the disease would be especially important. As a result, rational choice of the pertinent procedures become the clinical lynchpin. This paper reviews domestic and international pertinent literatures in the past 10 years, and provide an overview of the latest study of anatomy, biomechanic, pathomechanism and clinical experience, anticipating to offer help on standardizing the diagnosis and treatment of ELPS.

Injury and reconstruction of medial patellofemoral ligament / 中国骨伤

Medial patellofemoral ligament (MPFL) is the major static structure to restrain lateral patellar dislocation. There are always MPFL injuries in patellar dislocations. The medial ligamentous deficiency will lead to recurrent patellar dislocation or patellar instability. Surgeon used to suture all those structures in the medial knee compartment before MPFL is recognized. Reconstruction of MPFL becomes an important method to treat patellar dislocation since it is anatomically recognized. Many techniques have invented MPFL reconstruction. The goal of this article is to develop a current understanding of MPFL and its clinical significance, especially MPFL reconstruction. The anatomical double bundle reconstruction of MPFL by bone anchors is a safe, easy and effective way to treat patellar dislocations.

Comparison of the clinical outcome of anterior cruciate ligament reconstruction using allograft anterior tibialis and autologous hamstring tendon / 中国骨伤

<p><b>OBJECTIVE</b>To compare the clinical outcomes of ACL reconstruction using allograft anterior tibialis and autologous hamstring tendon.</p><p><b>METHODS</b>From September 2005 to May 2007, 100 ACLs were reconstructed, allograft were inplanted in 50 patients and autograft 50 patients. Rigidfix and Intrafix were used for graft fixation. The symptoms and objective signs were compared between two groups. Lysholm score were used for outcome evaluation.</p><p><b>RESULTS</b>There were neither infection nor rupture of the reconstructed ACLs in all patients. All patients were followed and the average follow-up period was 25.6 months (range 12 to 33). There was no positive pivot shift sign in two groups, the anterior drawer test (ADT)and Lachman test were negative or grade I positive. There was no difference in Lysholm scores between two groups(89.3 allograft vs. 90.5 autograft, P>0.05).</p><p><b>CONCLUSION</b>These data suggest that there are no differences in clinical outcomes of ACL reconstruction with allograft anterior tibialis tendon and autologous hamstring tendon.</p>

Application of absolute alcohol in operations for giant meningiomas with rich blood supply / 中华神经医学杂志

Objective To evaluate the effectiveness of absolute alcohol in hemostasis in surgical resection of giant meningiomas with rich blood supply. Methods Twelve patients with giant meningiomas with rich blood supply were injected with absolute alcohol (8.5-27 mL, mean 11.2 mL) in the operations, and the tumors were resected under microscope. Results The tissues in the injection areas turned white and the tumors became hardened after the injection. The bleeding of the tumor surface and section was obviously decreased or even stopped. The quantities of bleeding were 48-154 mL in the operations, with an average of 67 mL. Total tumor resection was achieved in 11 patients (91.6%) and partial resection in 1 patient. No complications associated with the surgery were found in these cases. Conclusion Injection of absolute alcohol for hemostasis in surgical removal of giant meningiomas with rich blood supply is convenient and effective and can be widely applied in clinical practice.