Résumé
Vladimiriae Radix is a Tibetan medicine with national characteristics, which contains compounds such as sesquiterpene, lignin, and volatile oil. Pharmacological studies indicated that the sesquiterpenes in Vladimiriae Radix had good activity in the digestive diseases, liver and gallbladder pain, anti-inflammatory and antispasmodic. This review mainly integrated domestic and foreign researches, and summarized the advances in the chemical constituents and the pharmacological activities of Vladimiriae Radix systematically. It provides references and scientific basis for pharmacological study and utilization of Vladimiriae Radix.
Résumé
The chemical constituents of Herpetospermum caudigerum were investigated using chromatographic methods, including silica gel column chromatography, Sephadex LH-20 and semi-preparative HPLC. Four compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as 2,11-dimethoxy-3,9-dihydroxy-7H-dibenzo[c,e]oxepin-5-one (1), 7,8'-didehydroherpetotriol (2), herpetotriol (3) and kaempferitrin (4). Among those, compound 1 is one new 7H-dibenzo[c,e] oxepin-5-one, named as herpetolide C.