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1.
Chinese Journal of Medical Library and Information Science ; (12): 36-40, 2017.
Article Dans Chinois | WPRIM | ID: wpr-619588

Résumé

The Doha Declaration has entrusted to the members of WHO the right to use the compulsory licensing for drug patents in the face of global public health crises.Although the basic compulsory licensing system for drug patents has been established in China, the efficiency of its implementation is low, the responsibility of its executive departments is unclear, the related rules are not fully understood by pharmaceutical enterprises, it is thus necessary to improve and perfect the relevant legal provisions and systems in order to effectively improve the accessibility of drugs.

2.
China Journal of Chinese Materia Medica ; (24): 1491-1493, 2012.
Article Dans Chinois | WPRIM | ID: wpr-266990

Résumé

<p><b>OBJECTIVE</b>To establish the mothod to dectect the microdialysis recovery of HCPT and to investigate the influencing factors, thus to supply experimental basis for in-vivo microdialysis of HCPT.</p><p><b>METHOD</b>The in vitro recovery of HCPT was detected by concentration difference method (increment method and decrement method). The influence of flow rates, medium concentration and temperature on the HCPT recovery and the stability were studied.</p><p><b>RESULT</b>The recovery detected by increment method was the same as by decrement method. The recovery was independent of HCPT concentrations in the medium. The hydroxycamptothecine recovery had good stability and increased as the temperature rose.</p><p><b>CONCLUSION</b>Microdialysis sampling can be used for the pharmacokinetic study of HCPT. Retrodialysis can be used for the determination of the HCPT in vivo recovery.</p>


Sujets)
Camptothécine , Chimie , Stabilité de médicament , Microdialyse , Température
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