Role of Bougainvillea glabra Stem Extract on Paracetamol and Alcohol-Induced Hepatotoxicity in Rats

The current study investigates the in-vivo hepatoprotective effectiveness of Bougainvillea glabra stem extract against alcohol and paracetamol-induced hepatotoxicity in animal models. The alterations in liver enzymes including serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), and total bilirubin are studied in rats given B. glabra extract with paracetamol or alcohol to produce hepatotoxicity. The levels of glutathione and lipid peroxidation were also examined, and the outcomes were contrasted with silymarin as the reference. The acute toxicity studies presented the plant extract under category 5 of GHS system, which further motivated the studies for hepatoprotective activity. The induction of hepatotoxicity was confirmed with the elevated levels of serum and tissue biochemical by the administration of paracetamol and alcohol. Under paracetamol as a hepatotoxin, the animals with 200 and 400 mg/kg p.o demonstrated near figures for SGPT and SGOT of the group treated with silymarin with significance. The results were still more appreciative under alcohol as a hepatotoxin. In both cases, the group with 400 mg/kg p.o gave a promising result with the reduced inflammatory cells under histopathological studies.

STUDY OF EPIDEMIOLOGY AND ITS PROGNOSTIC FACTORS FOR EXPECTED THERAPEUTIC MANAGEMENT OUTCOME ALONG WITH THE ANTIHYPERTENSIVE DRUG PATTERN FOR PREECLAMPSIA IN RURAL SETTING

This study analyses the association between epidemiological factors and preeclampsia and the antihypertensive drug pattern used at different stages of preeclampsia. Total 252 patients were enrolled for study. Some of the study variables which were studied was maternal age, history of infertility, family income, education, antihypertensive drug used, body mass index of mother and baby’s birth weight. Study was performed SGT Hospital, Gurugram and was given ethical clearance by the Institutional Ethical Committee (IEC). Data was collected with the help of validated questionnaires. Occurrence of Pregnancy Induced Hypertension (PIH) in our study was found to be 47.2%. Maternal age, low socioeconomic status, less education level, >36 weeks of gestation are one of some major factors responsible for PIH. The current study implies that different dosage forms of labetalol was prescribed with P value <0.05.