In vitro screening for acetylcholinesterase inhibition of Baliospermum montanum, Humboldtia brunonis Wall. var. raktapushpa and Pittosporum viridulum.

Ethanolic extracts of three medicinal plants collected from South India were analyzed for their activity towards acetylcholinestrase (AChE) enzyme. The AChE inhibition was measured spectrophotometrically. All the three species namely, Baliospermum montanum, Humboldtia brunonis Wall. var. raktapushpa and Pittosporum viridulum showed substantial inhibitory activity towards acetylcholinesterase with IC50 values, 137.5μg/ml, 128.7 μg/ml and 105.3μg/ml, respectively.

Acute Lymphoblastic Leukemia with Treatment–Naïve Fanconi Anemia.

Fanconi anemia is known to have a predisposition to cancer, mostly associated with acute myeloid leukemia. We report an eight-year-old girl with treatment and naïve FA who developed acute-lymphoblastic-leukemia (ALL). She was initiated on chemotherapy but she failed to respond to treatment and died during induction phase of chemotherapy. While this association may be coincidental but possibility of transition of Fanconi anemia to ALL should be considered in view of high predisposition to cancer in this disorder.