Résumé
Patients deafened by a severe head injury are rarely encountered. We report a case of a 65-yr-old man with bilateral transverse temporal bone fractures due to head injury. He underwent cochlear implant and achieved a satisfactory auditory rehabilitation. Imaging studies of temporal bone before performing a cochlear implantation provide important information on a patient with bilateral temporal bone fractures. Cochlear implantations with careful planning in such a patient may be a very effective method for aural rehabilitation.
Sujets)
Humains , Implantation cochléaire , Implants cochléaires , Correction de la déficience auditive , Traumatismes cranioencéphaliques , Surdité neurosensorielle , Fractures du crâne , Os temporalRésumé
BACKGROUND: Genistein and daidzein are two major soybean isoflavones. They have received increasing attention because of their possible roles for cancer prevention. However, their mechanisms of action and molecular targets on the human colon cancer cells are not fully understood. METHODS: Human colon cancer HCT-116 cells were treated with genistein and daidzein to investigate their effects on the cell growth and this was analyzed with MTT assay. TUNEL assay and Hoechst33342 stain were carried out to identify apotosis. RESULTS: Daidzein was able to inhibit cell proliferation and induce apoptosis of the HCT-116 cells, but genistein didn't affect the cell growth. The ER antagonist ICI182780 didn't attenuate the antiproliferative and proapoptotic effects of daidzein: this means the effect of daidzein on the HCT-116 cells may not be dependent on the ER pathway. The other soybean isoflavone, genistein, attenuated the effects of daidzein on the HCT-116 cells and its mechanism should be elucidated. CONCLUSIONS: These data suggest that daidzein may act as a preventive agent on human colon cancer, and its mechanism of action doesn't involve the ER-dependent pathway.
Sujets)
Humains , Apoptose , Prolifération cellulaire , Côlon , Tumeurs du côlon , Génistéine , Cellules HCT116 , Méthode TUNEL , Isoflavones , Glycine maxRésumé
Septic thrombophlebitis results from extensive infection of the lateral pharyngeal space to the jugular vein and generally occurs in healthy adolescents and young adults. This disease can disseminate to multiple distant sites such as joint, liver, kidney, eye, bone, and especially lung, and can lead patients into fatal condition. Contrast enhanced computed tomography and ultrasonography are good diagnostic methods for external jugular vein thrombophlebitis (EJVT). Treatment of EJVT includes intravenous antibiotics and surgical drainage of abscess, ligation or excision of the jugular vein, in addition to fibrinolytic agents and anticoagulants. With a review of literature, authors report a case of external jugular vein thrombophlebitis with sepsis which has successfully been managed by ligation and excision of the vein.
Sujets)
Adolescent , Humains , Jeune adulte , Abcès , Antibactériens , Anticoagulants , Drainage , Fibrinolytiques , Articulations , Veines jugulaires , Rein , Ligature , Foie , Poumon , Sepsie , Thrombophlébite , Échographie , VeinesRésumé
Several approaches to the cerebellopontine angle and internal auditory canal have been described for the removal of large acoustic tumors. Of these, the translabyrinthine removal of the large cerebellopontine angle tumors requires extensive removal of bones in order to manage the low-lying tegmen, the anterior sigmoid sinus, and the high jugular bulb. We removed 4 large cerebellopontine angle tumors by the translabyrinthine approach alone. All tumors were totally removed with acceptable facial nerve function. There was a case of CSF leak which was repaired at the revision surgery.