Résumé
Sjogren's syndrome is a systemic autoimmune disease characterized by sicca symptoms and B lymphocyte hyperactivity. Hematological abnormalities are common in Sjogren's syndrome, including anemia, leukopenia, thrombocytopenia, and lymphoproliferative disorders. These hematologic involvements are mostly recognized as mild laboratory abnormalities. Life-threatening, severe thrombocytopenia is very rare. We describe a patient with primary Sjogren's syndrome, who developed very severe thrombocytopenia during the clinical course and successfully treated with high dose dexamethasone therapy.
Sujets)
Humains , Anémie , Maladies auto-immunes , Dexaméthasone , Leucopénie , Lymphocytes , Syndromes lymphoprolifératifs , Purpura , Syndrome de Gougerot-Sjögren , ThrombopénieRésumé
We describe a fatal case of invasive pulmonary aspergillosis in a patient with rheumatoid arthritis receiving the TNF-alpha inhibitor, adalimumab. The use of TNF-alpha inhibitor has been associated with an increased risk of infections, including tuberculosis and other opportunistic infections. Physicians should have a high index of suspicion for opportunistic infection that can develop during TNF-alpha inhibitor treatment.