Résumé
<p><b>OBJECTIVE</b>To investigate the expression and significance of transforming growth factor-β(1) (TGF-β(1)) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma.</p><p><b>METHODS</b>The expression of TGF-β(1) and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method.</p><p><b>RESULTS</b>Expression of TGF-β(1) (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma (P < 0.05). TGF-β(1) expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma (16/16) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) (P < 0.05), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12) (P > 0.05). The expression of Ki-67 was increased with the increment of TGF-β(1) expression in mucoepidermoid carcinoma (P < 0.05).</p><p><b>CONCLUSIONS</b>The high expression of TGF-β(1) may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.</p>
Sujets)
Adolescent , Adulte , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Adénome pléomorphe , Métabolisme , Anatomopathologie , Carcinome mucoépidermoïde , Métabolisme , Anatomopathologie , Différenciation cellulaire , Antigène KI-67 , Métabolisme , Tumeurs des glandes salivaires , Métabolisme , Anatomopathologie , Facteur de croissance transformant bêta-1 , MétabolismeRésumé
<p><b>OBJECTIVE</b>To investigate an safe and effective new technology (treatment) to repair maxillofacial region penetrating defect.</p><p><b>METHODS</b>The lower trapezius musculocutaneous flap is parallel just like as two leaves which is connected to each other, and was folded to provide the liner of oral cavity and external cover.</p><p><b>RESULTS</b>Totally twelve folding lower trapezius musculocutaneous pedicle flap survived. Postoperative follow-up for 1 approximately 3 years, the patients restored the function as well as the shape of maxillofacial region.</p><p><b>CONCLUSIONS</b>The lower trapezius musculocutaneous pedicle flap is a suitable material for maxillofacial region reconstruction, further more, the successful rate is perfect.</p>