Résumé
A bibliometric analysis was performed on Science Citation Index Expanded (SCIE) from the aspects of the amounts of publications and citations, language, journals, subject categories, organizations, and international collaborations. The amounts of total publications and citations of China have largely exceeded Japan and Korea, and the amounts of citations per article are close to each other. More than 97% of papers are written in English. The impact factors of Top 10 journals sorted by number of publications are from 1 to 3. The most appear categories are integrative & complementary medicine, pharmacology & pharmacy, and chemistry. Pharmacology pharmacy, chemistry, and biochemistry molecular biology are the Top 3 subjects that sorted by the number of publications of traditional Chinese medicine (TCM). Both the amount of publications and citations of the Top 3 subjects are bigger than the subject of integrative complementary medicine. Chinese academy of science and comprehensive universities, whose amount of publications and citations per article are generally higher than universities of TCM, are important participants in the research of TCM. The rate of international collaboration of China is lower than those in Japan and Korea. The number of citations per article of international collaboration publications is higher than domestic publications. The research ability of scientists from China, Japan, and Korea is close to each other in the subject of TCM. But China has advantages in the amount of publications and citations. For TCM, the development of pharmacology pharmacy is ahead of therapeutic method. Compared with Chinese academy of science and comprehensive universities, TCM universities need to improve their scientific performance. Because the international scientific collaboration is insufficient, scientific international collaborations need to be strengthened by researchers from China.
Résumé
<p><b>OBJECTIVE</b>This study was to elucidate the role of human papillomavirus (HPV) types and cofactors in the development of cervical intraepithelial neoplasia (CIN).</p><p><b>METHODS</b>Two hundred and twelve women with CIN and 427 women with normal cervical cytology (control group) were recruited from China and Australia. A questionnaire was administered to each participant to obtain the demographic and risk factor information. Cervical biopsies or smears were taken to detect HPV DNA by PCR and to identify HPV types by direct sequencing and/or Amplicor hybridisation. Data were analyzed by logistic regression.</p><p><b>RESULTS</b>HPV prevalence rates of specimens from Chinese and Australian were 11% and 15% among controls (P >0.05), with 99% and 85% of CINs (P<0.001), respectively. The presence of any type of HPV DNA was strongly associated with CIN with OR 43.3 for Chinese and OR 541.6 for Australian women. The strongest risk was for HPV16,followed by HPV31 in Australians, but HPV58, 59 in Chinese women. The risk for multiple HPV infection was stronger in the Australians than that in the Chinese cohort. Except for HPV infection, educational attainment was unexpectedly associated with an increased risk for CIN in Chinese, and cancer history in family was a risk factor for Australians. For the combined cohorts, educational attainment, and frequency of vitamin consumption were identified to be risk factors for CIN.</p><p><b>CONCLUSION</b>Cervical HPV DNA was a major risk factor, with the highest relative risk for type 16 HPV infection for CIN. There were variations in the distribution of HPV genotypes and cofactors in China versus Australia and in CIN.</p>