Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Clinics ; 70(11): 751-757, Nov. 2015. tab, graf
Article Dans Anglais | LILACS | ID: lil-766151

Résumé

OBJECTIVES: This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers. METHODS: Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups. One group served as the control (group 1), whereas the other three groups (groups 2-4) were administered L-NAME (25 mg/kg, intraperitoneally). Groups 3 and 4 were given oral nicardipine daily at a dose of 3 mg/kg and Nigella sativa oil at a dose of 2.5 mg/kg for 8 weeks, respectively, concomitantly with L-NAME administration. RESULTS: Nigella sativa oil prevented the increase in systolic blood pressure in the L-NAME-treated rats. The blood pressure reduction was associated with a reduction in cardiac lipid peroxidation product, NADPH oxidase, angiotensin-converting enzyme activity and plasma nitric oxide, as well as with an increase in heme oxygenase-1 activity in the heart. The effects of Nigella sativa on blood pressure, lipid peroxidation product, nicotinamide adenine dinucleotide phosphate oxidase and angiotensin-converting enzyme were similar to those of nicardipine. In contrast, L-NAME had opposite effects on lipid peroxidation, angiotensin-converting enzyme and NO. CONCLUSION: The antihypertensive effect of Nigella sativa oil appears to be mediated by a reduction in cardiac oxidative stress and angiotensin-converting enzyme activity, an increase in cardiac heme oxygenase-1 activity and a prevention of plasma nitric oxide loss. Thus, Nigella sativa oil might be beneficial for controlling hypertension.


Sujets)
Animaux , Mâle , Antihypertenseurs/pharmacologie , Pression sanguine/effets des médicaments et des substances chimiques , Hypertension artérielle/traitement médicamenteux , Nigella sativa/composition chimique , Huiles végétales/pharmacologie , Antihypertenseurs/administration et posologie , Heme oxygenase (decyclizing)/métabolisme , Hypertension artérielle/induit chimiquement , Modèles animaux , Malonaldéhyde/analyse , NADPH oxidase/métabolisme , L-NAME , Nicardipine/administration et posologie , Nicardipine/pharmacologie , Monoxyde d'azote/sang , Stress oxydatif/effets des médicaments et des substances chimiques , Peptidyl-Dipeptidase A/métabolisme , Rat Sprague-Dawley
SÉLECTION CITATIONS
Détails de la recherche