Résumé
Lavandula angustifolia was used to treat flus and fevers, joint swelling and pain in Uighur medicine. This study aimed to investigate antioxidant, antit anti-inflammatory and antalgic noids content [530.1mg/g rutin/g dry extract] with stronger DPPH scavenging abilities and reduciactivities of total flavonoids from Lavandula angustifolia [LTF]. Results indicated that LTF possesses the highest total flavong power. Some flavonoids separated from LTF, and their DPPH scavenging abilities as follows: rosmarinic acid [2, near to Vit C] >luteolin [3] >apigenin [4] >luteolin 7-O-beta-D-glucoside [5] >apigenin 7-[O-beta-D-glucoside [6] >luteolin 7-[O-beta-D-glucuronide [7]. LTF significantly decreased malondialdehyde [MDA] level in D-galactose induced aging model compared to the control group [P<0.05], as well as significantly increased plasma superoxide dismutase [SOD] and glutathione peroxidase [GSH-Px] activities [P<0.05]. Moreover, 17.4, 34.8 and 69.6 mg/kg doses of LTF were exhibited significant analgesic and anti-inflammatory activities in a dose dependent manner [P<0.05]. Cytotoxicity of LTF on Bel-7402 and Hela cell lines were showed by MTT assay also. These results verified traditional usage of this plant and suggested also that LTF is worth developing and studying further