Serum IgE and Peripheral Blood T-Lymphocytes in Parientis with Atopic Dermatitis / 대한피부과학회지

During recent years, many investigators studied to confirm the pathogenesis of atopic dermatitis but it remains obscure. However, two major proposals, the B-padrenergic blockade hypothesis of Szentivanyi and the immunological hypothesis, have been advanced. The significant role of IgE in the pathogenesis of atopic dermatitis was considered since the discovery of elevated IgE levels in atopic dermatitis in 1969. However, recent various reports have indicated the existence of immune defects not only in humoral but also in cellular immune status of patients with atopic dermatitis. This study was undertaken to assess the humoral and cellular immune status of patients with atopic dermatitis using in vitro immune parametera The relationship between the humoral and cellular immune status of atopic subjects and the severity of disease was examined reapectively. The effect of the corticosteroid administration on the serum IgE levels of the patients with atopic dermatitis was followed. Eighty-three patients with atopic dermatitis, diagnosed and treated at the Department of Dermatology, Soon Chun Hyang University Hospital from October, 1988 to September, 1981 and twenty-one normal healthy subjects were included in this: study. Serum lgE levels were measured by Phadebas IgE (paper radio-immunosorbent technique) and peripheral blood T-lymphocytes (early and total) wer enumerated by the E-rosette technique.

A Case of Herpes Gestationis / 대한피부과학회지

Herpes Gestationis is a rare polymorphous, vesiculobullous disease of pregnancy and puerperium. It is characterized by rapidly progressive skin eruption heraled initially by severe generalized pruritus. Erythematous papules and urticaria like plaques rapidly appear followed by grouped, tense, vesiculobullous eruptions. A 23 year-old pregnant woman was admitted to our departrnent of dermatology hecause of erythematous patches with pruritic vesiculobullous and pustular eruption on the whole body since third week of conception, Biopsy specimen of bullous skin lesion showed spongiosis of epidermal cells, mild necrosis of basal cells, subepidermal bulla, edema, of papillary derrnis and perivascular infiltration of inflammatory cells. Ultrastructural findings showed mild necrosis of basal cells, bulla above or below basement membrane zone and partial separation of basal larnina. Direct immunofluorescences of bullous lesion and normal appearing skin demonstrated deposition of IgG in linear pattern along basement rnembra,ne zone. After treatment with systemic corticosteroid and antihistamin, the lesions were cleared, leaving residual hyperpigmentation, and she delivered normal female baby.

Two Cases of Superficial Migratory Thrombophlebitis / 대한피부과학회지

Superficial migratory thrombophlebitis (SMT) represents multiple, tender, often cordlike nodules, usuallyion the legs but occationally on the arms. In some instances the nodules slowly migrate along the course of a vein. It can occur in association with carcinoma of internal organ or other diseases but also idiopathically. In 1865 Trousseau first wrote about that patients who have carcinoma involving an internal organ are prone to develop thrombophlebitis in one or more superficial veins so he drew attention to the fact that thrombophlebitis may be a first presenting sign of carcinomatosis. In fact, it is not uncommon for the ordinary thrombotic lesions to be observed several months or even a year before the carcinoma would otherwise diagnosed. So the clinical manifestation of SMT may be very important dermatologic finding to find hidden cancer of visceral organ. We present two cases of SMT, first case is a 25-year-old male patient who had multiple, tender nodules on both lower extremities and second case is 32-year-old male patient who had multiple, tender, linear, often cordlike nodules along the inner aspect of right lower extremity. Because we could not find any internal carcinoma or other diseas esexcept histories of hepatitis, we regard them as idiopathic type, but continuous follow up observation must be needed under the importance of possible presence of internal carcinoma.