Exogenous lipoid pneumonia caused by Nigella sativa oil - A case report

Introduction: Exogenous lipoid pneumonia [ELP] is an uncommon and chronic infiltrative pulmonary process secondary to continued aspiration of exogenous lipids. Nigella sativa, or the black cumin seed, is a herb used in traditional medicine in many Middle Eastern and Asian countries to treat a broad array of diseases

Objective: The purpose of the present case report is to reveal the role of the abuse of N. sativa seed oil [black cumin seed oil], as an exceptional cause of ELP, which has not been, to our knowledge, previously documented

Case report: A 50-year-old man was evaluated for a 6-month history of cough, sputum and progressively worsening dyspnea on exertion. His medical history included long-term smoking. We questioned the patient specifically about use of any traditional herbal medicinal products. He acknowledged that he had been taking one tablespoon [15 ml] of N. sativa oil at bedtime since 8 months [8 bottles of 500 ml] for the purposes of tonification. Exogenous lipid pneumonia was suspected. Physical examination found bilateral crackles of the lung bases. Lung function tests were normal. The chest radiograph showed thoracic distension and bilateral basal interstitial disease. Computed tomography [CT] of the chest was performed, and revealed infiltrative lung disease affecting the posterobasal segments of the right and left lower lobes, honeycomb fibrosis was seen at the bases of both lungs. Routine blood tests were normal. Sputum and blood culture were sterile. We performed bronchoscopy with transbronchial biopsies and bronchoalveolar lavage. The color of the lavage liquid was blakish with fat globules on the fluid surface. It contained 220,000 cells/ml. Differential cell count showed 87% macrophages, 13% lymphocytes; stains and cultures for infectious agents were negative. The patient was advised to stop taking N. sativa oil. The only treatment that was instituted was N-acetylcysteine. A clinically significant change in symptoms and chest radiograph was observed. The patient has remained stable 18 months after the diagnosis

[ acute liver failure [ALF] in children - about 55 cases]

The acute liver failure [ALF] in children has multiple etiological factors.. In our context, the infectious, especially viruses, are in the first rank. In this study, the authors report 35 cases of ALF, diagnosed and treated in our unit, between January the 1st 2003 to february 28[th], 2006 for analyzing the clinical, biochemical characteristics, the evolution as well as the treatment. The age of the patients varies between 2 months to 14 years old. Clinically, the jaundice was noted at 57% of the patients, are bleeding 28%, a hepatomegaly 41% with cirrhotic once at 17% and a generalized edema at 34%. A hepatic encephalopathy was noted in 11% of the patients. On the biological parameters: the rate of prothrombin [RP] was lower than 50% in 82% of cases, the hepatic cytolysis was noted in 88% of cases, the hypoalbuminemia in 40% and low blood glucose in 43% of the patients. Concerning etiologies, the infectious origin accounts for 45%, followed by Wilson disease with a rate of 19%. The treatment is in all cases symptomatic; it was etiologie each time that a cause was identified. The death of 3 patients is deplored. The infectious origin remains the dominant cause in our department, represented primarily by hepatitis A and the leishmaniosis, followed by the Wilson's disease. The high mortality must encourage rapid evaluation and selection of the patients candidates to liver transplant

Dyspnea: Mechanisms and assessment

This work studies the pathophysiological mechanisms of dyspnea and describes the assessement of intensity of dyspnea. The study of mechanisms of dyspnea show that dyspnea can result from a respiratory muscle dysfunction, an excessive stimulation and/or alteration of pulmonary and extrapulmonary receptors, and a direct and excessive stimulation of respiratory centres. The assessment of dyspnea can be made generally by indirect methods based on questionnaires and direct methods based on psychophysiology techniques. The understanding of pathophysiological mechanisms and the study of the assessment of dyspnea represents the key principles in strategy and effectiveness of the dyspnea treatment