[Effect of continuous aerobic training on serum levels of liver injury indices in rats with myocardial infarction]

Introduction: In this study, the effect of continuous aerobic training on serum indices of liver tissue damage enzymes [aspartate aminotransferase [AST], alanine amino transferase [ALT], and alkaline phosphatase [ALP]] in rats with myocardial infarction [MI] were evaluated. Material and Methods: For this purpose, four weeks after MI, 30 male Wistar rats were randomized to the following groups: 1: Sham [n=10]; 2: MI-sedentary [Sed-MI], n=10 and 3: MI-exercise [Ex-MI], n=10 the rats were subjected to aerobic training in the form of treadmill running for 10 weeks [5 days per week] at 17 m/min for 50 min/day. At the end of training program, serum AST, ALT, and ALP were measured by ELISA kits. Results were analyzed by one-way analysis of variance [ANOVA] and P<0.05 was considered as significant level. Results: AST activity, in the MI-sedentary and MI exercise groups was significantly higher at the end of training [p=0.01], there was however no significant difference between MI-sedentary and MI-exercise [p=0.93]. Alanine amino transferase was also significantly increased after MI [p=0.02], there was howere no significant difference between MI-exercise and the MI-sedentary groups [p=0.55]. ALP activity was comparable between groups [p=0.9]. Conclusion: Ten weeks continues aerobic exercise training with moderate intensity had no effect on liver function in rats with MI. To better evaluate the effect of exercise training on liver pathological indices immunohistochemical analyses are needed

[Effect of gender and physical activity on serum vascular endothelial growth factor at rest and response to submaximal exercise]

Although the effects of exercise on angiogenic factors is a topic that has attracted the attention of many researchers worldwide, the possible impacts of gender and physical activity on the rate of angiogenic factors at rest and response of acute exercise have not been investigated so far and which is why we conducted this research. Sixteen women [8 active, 8 sedentary] and 16 men [8 active, 8 sedentary] participated in this study. Three days after determination of V02max, they exercised for 1 h at 70% V02 max. Serum was collected from the vein at rest and at 0 and 2 h, post exercise. Serum vascular endothelial growth factor [VEGF] was measured by ELISA kits. Serum levels of VEGF decreased immediately after exercise in groups, a change that was temporary and transient. At rest, no difference between serum VEGF of groups was seen. On the other hand, changes in VEGF levels in response to exercise between groups were not significant. Acute submaximal exercise decreases the main angiogenic factor involved in development of capillary network. Gender and physical activity do not affect serum levels of the vascular endothelial growth factor at rest or response of exercise