Résumé
Our objective was to determine the vitamin D profile in Moroccan lupus patients. This is a retrospective study performed in the immunology laboratory of the Faculty of Medicine and Pharmacy of Casablanca, concerning 84 patients with Systemic Lupus Erythematosus confirmed by the revised criteria of American College of Rheumatology. 25-hydroxy-vitamin D [25 [OH] D] was assayed by an enzyme immunoassay [ELISA]. Status of vitamin D sufficiency is defined by a serum concentration of 25 [OH] D beyond 30ng/ml. After studying the clinical records of patients, an evaluation based on both of the vitamin D status and the associated systemic involvement was performed. The mean age of patients was 34.2 +/- 9.1 years, with extremes of 14 and 69, 85% of patients were female [sex ratio: 0.18]. The mean serum 25 [OH] D is 24ng/ml with a rate of 28 +/- 8.3 ng/ml in women, and 15 +/- 7.4 ng / ml in men. 67.7% of patients are vitamin D insufficient, and 15.1% are deficient. The lowest concentrations of 25 [OH] D were obtained in patients with glomerular disease with an average of 11ng / ml. Low levels of vitamin D should be common among Moroccan lupus patients. Studies in this direction are needed to confirm our results and to better understand the role of vitamin D in the prevention and the treatment of SLE and autoimmune diseases in general
Résumé
Systemic Lupus Erythematosus is an autoimmune disease characterized by the production of a heterogeneous group of autoantibodies: unavoidable element for diagnosis, prognosis and therapeutic monitoring. The aim of this study was to establish the profile of some autoantibodies in Moroccan lupus patients. This is a prospective study conducted over six months, in the Immunology Laboratory of the Faculty of Pharmacy and Medicine of the University Hassan II of Casablanca, including 30 patients with Systemic lupus erythematosus. The average age of our patients was 34, 6 years, with a female predominance [sex-ratio: 0, 2] Clinical signs were polymorphic, dominated by hematological [25 cases], skin [22 cases], rheumatological [21 cases] and kidney disorders [8 cases]. Immunologically, anti-nuclear antibodies were positive in 77% of cases, and anti-dsDNA in 73, 9% of cases. For soluble anti-antigen antibodies, they were dominated by anti SSA antibodies [52%]. The involvement of anti-dsDNA and anti-SSA in disease activity was deducted, hence the crucial importance of systematic research of these autoantibodies for regular monitoring of lupus patients preventing the occurrence of systemic manifestations