Effects of different intravenous anaesthestics on free radicals in polytraumatized patients

Oxygen free radicals are highly reactive and potentially destructive. In the normal cells there are always a small number of free radicals produced, but cell enzymes easily deal with them. The aim of this study is to detect the effects of trauma and thereafter different intravenous anaesthesia on free radical production in individuals with multiple injuries. This study was performed on 40 individuals. They were divided into 2 groups; trauma group [n = 20] and non trauma control group [n =20]. Both groups were matched as regard age, sex and body weight. Each group was classified according to the type of intravenous anaesthesia used into ketamine- fentanyl group [n =10] and propofol- fentanyl group [n=10]. Estimation of plasma malondialdhyde [MDA] and blood superoxide dismutase [SOD] and glutathione per-oxidase [GPX] levels was done. The results of this study revealed significant increase in MDA levels and significant decrease in SOD and GPX level in trauma group in comparison with control one. On the other hand, propofol and ketamine induced decrease MDA levels during the three stages of study in both groups in comparison to their corresponding basal values. Also, propofol and ketamine induced significant increase in GPX levels after induction in traumatic and control groups when compared with their basal values. However, propofol produced significant increase in SOD levels after induction in traumatic and control groups when compared with their basal values. From this study, we conclude that propofol and ketamine decrease free radicals generation while propofol increased the antioxidant scavengers than ketamine. So, propofol could be more beneficial than ketamine for anaesthesia of polytraumatized individuals, which have oxidant and antioxidant imbalances

effect of suxamethonium administration on serum potassium level in bilharzial and non-bilharzial patients

This study was conducted on 4 groups of patients two of them were complaining of bilharzial hepatic fibrosis. Serum K level was estimated pre, 4, 8, 12 minute after administration of suxamethonium and also after halothane induction. There was significant increase in serum potassium level after four and eight minutes following suxamethonium administration as compared to that before suxamethonium. It returned to normal level after twelve minutes. In bilharzial patients there was no significant change in serum potassium level after four, eight and twelve minutes following suxamethonium injection. Serum potassium level in the second and third groups showed no significant change. There was significant decrease in serum potassium level after four minutes from halothane induction in bilharzial patients as compared to normal ones

effect of haemorragic shock on the lungs and heart of dogs, a histochemical study

Six mongrel dogs were subjected to haemorragic shock gy lowering systolic arterial tensien from 120-130 mmHg to 50 mmHg. Their heart and lungs were studied histoachemically after three hours of hypotention and compaired with two control animals. The myocardium showed diminished acid phosphatase activity, the enzyme being liberated from the disrupted lysosomes and esaping from the cells. Lysosomal discruption liberates lysosomal hydrolytic enzymes causing cell damage with escape of cell constituents. Lactic dehydrogenase activity was supposed to increase to cope with increased latic acid production but it was diminished owing to its escape from myocardial cells. Nonspecific esterase showed no change in activity probably due to its increased activity being balanced by its escape from the cells. Its activity probably is related to the change in substrate utilization by the hypoxic myocardium. Alkaline phophatase activity increased denoting enhancenment of transfer across capinary endothelium. The same explanation are true regarding the lung, but being more tolerant to hypoxia, these enzymes did not escape from the cells by the end of the experiment thus showing increased intracellular activity