Assessment of multiple drug resistance and sensitivity to helicobacter pylori in patients with peptic ulcer disease

Helicobacter pylori [H.pylori] is implicated in acute superficial gastritis, chronic atrophic gastritis, gastric carcinoma and MALT [Mucosa Associated Lymphoid Tissue] associated lymphoma. Prevalence of H. pylori antibiotic resistance is increasing and affect the efficacy of treatment. Our aim was to improve infected patients with new generations of antibiotics. 88 peptic ulcer patients recruited from gastroenerology and endoscopy unit at Suez Canal University, 5 gastric biopsies were taken from each and were examined for H. pylori by histopathology, rapid urease test and culture. Antibiotic susceptibility test was performed to: metronidazole, clarithromycin, amoxicillin, amoxicillin calvulanic acid, levofloxacin, tetracycline, ciprofloxacin, ofloxacin, ceftriaxone, cefoperazone and ceftazidime. Night-two% were positive for H. pylori, while 20% of the studied population were positively cultured .The results of antibiotic sensitivity were:100% of patients were sensitive to clindamycin, 87.5% sensitive to erythromycin, 68.8% sensitive to amoxicillin and levofloxacin, 50% sensitive to azithromycin and tetracycline, 25% sensitive to clarithromycin and 18.8% sensitive to amoxicillin and cavulanic acid. H. pylori resistance towards different antibiotics has increased. new promising results regarding clindamycin and erythromycin

Determinants of the duration of lactational amenorrhea among mothers in Alexandria

This study was undertaken to reveal some determinants of the duration of lactational amenorrhea. A total of 300 women nursing a child aged 6 to 24 months were selected using the cluster sample technique. All were subjected to an interview questionnaire to reveal the sociodemographic and biological characteristics of the selected women. Data were analyzed using the Kaplan-Meier survival and the Cox regression analyses. At the time of the interview, 20% of the women were still amenorrheic and 80% regained their menses. The mean survival time for lactational amenorrhea was 5.5 months [95% confidence interval was 4.8, 6.2 months]. Results of the present study revealed that early initiation of breast feeding, refraining from providing the infant with glucose immediately after delivery and delaying the age of the infant's supplementation are significant predictors of a longer duration of postpartum amenorrhea. On the other hand, the duration of lactational amenorrhea was found to be significantly shorter among women with higher family income, those who attended for antenatal care as well as those who received vitamin and mineral supplements during pregnancy. The multivariate Cox regression analysis revealed that seeking antenatal care [hazard ratio=1.24, P=0.0464] and time of initiation of breast feeding [hazard ratio=1.07, P=0.0474] as well as the infant's age at the time of supplements' introduction [hazard ratio=1.17, P=0.300] are the only significant independent determinants of duration of lactational amenorrhea. It was concluded that lactational amenorrhea is a natural method of contraception similar in effect to other modern contraceptive technologies. Therefore, maintaining that amenorrhea and in turn fertility suppression might have an impact on population fertility rates. The results of this study showed that some general and specific behavioural factors of breast feeding might explain the differences in the length of lactational amenorrhea in certain groups of women.For prolonging the duration of lactational amenorrhea health education regarding the good breast feeding practices is of crucial value

Helicobacter pylori infection associated with gastroesophageal reflux in patients with bronchial asthma: effect of eradication

This study explored the effect of Helicobacter pylori [Hp] eradication on chronic asthma patients with GERD associated with Hp infection. Forty-five adult patients with chronic moderate to severe asthma and GERD associated Hp infection were randomly assigned to three groups. Group I [triple therapy group] [n = 15] received 1000 mg amoxicillin bid and clarithromycin 500 mg bid for two weeks and omeprazole 20 mg bid for three months, Group II [omeprazole group] [n = 15] received omeprazole 20 mg bid for three months and Group III [control] [n = 15] received placebo for three months. Observation continued for three months after drug trial phase [wash out phase]. It was concluded that Hp has significant role in chronic asthma patients associated with GERD and its eradication results in long term improvement of both asthma and GERD