1.
Egyptian Journal of Pharmaceutical Sciences. 1997; 38 (4-6): 303-317
Dans Anglais
| IMEMR
| ID: emr-44550
Résumé
A series of pyridazinone derivatives carrying benzoheterocycles, such as benzoxazole and benzoxazine, was synthesized and tested as inhibitors of cAMP phosphodiesterase enzyme [PDE]. The most promising compound in this series was 6-[2,4-dioxo-3,4-dihydro- l,3[2H]-benzoxazin-6-yl]-4,5 dihydropyridazin-3[2H]-one [3], which showed potent inhibiting activity on cAMP PDE and was ten times more potent than milrinone [a commercially available cardiotonic agent]
Sujets)
Benzoxazoles/synthèse chimique , Cardiotoniques/synthèse chimique , Benzoxazoles/analogues et dérivés
2.
Egyptian Journal of Pharmaceutical Sciences. 1997; 38 (4-6): 319-331
Dans Anglais
| IMEMR
| ID: emr-44551
Résumé
A series of 6-[4-[substituted-amino]phenyl] pyridazinones and related compounds were synthesized and evaluated as inhibitors of cardiac cyclic AMP phosphodiesterase. Compounds 2c, 2d, 2h showed potent inhibitory activity and were found more potent than milrinone