Ultrastructure of human endometrium in cases of dysfunctional uterine bleeding having normal light microscopic findings

The ultrastructure of endometrial biopsies from 20 women suffering from dysfunctional uterine bleeding and diagnosed as being histologically normal by light microscopy were studied by transmission electron microscopy. The gl and cells showed enlarged mitochondria and defect in the development of nucleolar channel system. The blood vessels exhibited early degenerative changes of endothelial cells and focally disrupted areas of basement membrane. Open junction between endothelial cells were frequently observed; thus, electron microscopic examination revealed that vessel damage plays a major role in dysfunctional uterine bleeding. Delay in maturation of some gl and cells with consequent delay in healing resulting in prolonged bleeding was suggested as another factor. It was concluded that in endometria of women suffering from dysfunctional uterine bleeding, electron microscopy might reveal structural abnormalities not revealed by ordinary light microscopy. The clinical impact of those observed electron microscopic changes needs further elucidation

Coagulation and hemostatic parameters in healthy upper Egyptian women of child bearing age

In this study, hemostatic and coagulation parameters were measured for 583 healthy Upper Egyptian women in their reproductive age using standardized laboratory tests. The results were compared with values reported for healthy women in other countries and showed that Upper Egyptian women have significantly and consistently different values from those reported for women of other localities. Upper Egyptian women have shorter screening tests, lower coagulation factors activity, higher antiproteinase and stronger platelets aggregation and the majority of platelets were in the second channel i.e. Between 5 and 13 fL. These differences can explain, at least partly, the difference in the incidence of hemostatic and coagulation disorders between different ethnic groups

Coagulation and hemostatic parameters in healthy upper Egyptian women of child bearing age

In this study, hemostatic and coagulation parameters were measured for 583 healthy Upper Egyptian women in their reproductive age using standardized laboratory tests. The results were compared with values reported for healthy women in other countries and showed that Upper Egyptian women have significantly and consistently different values from those reported for women of other localities. Upper Egyptian women have shorter screening tests, lower coagulation factors activity, higher antiproteinase and stronger platelets aggregation and the majority of platelets were in the second channel i.e. Between 5 and 13 fL. These differences can explain, at least partly, the difference in the incidence of hemostatic and coagulation disorders between different ethnic groups

Oral versus vaginal administration of a combined hormonal contraceptive Pill: a comparative study of efficacy, acceptability and side effects

This work investigate the possibility of using combined contraceptive pill per vaginum instead of oral use. Neovlar [0.25 mg Levonorgestrel and 0.05 mg of ethinyl estradiol was used for contraception via the oral route by 51 healthy fertile women and per vaginum by 49 women, the allocation to either groups was random. Both groups were clinically comparable at admission and used the pills for 21 days alternating with 7 days of pill free period. They were monthly followed up for one year. The first year continuation rates were 92.1 +/- 3.8 [rate +/- S.E. and 93.8 +/- 3.4 for the oral and vaginal routs respectively; a statistically insignificant difference. The first year net cumulative pregnancy rate was 2/100 women for the oral pill users and 4.2/100 women for women who used the vaginal route. Headaches, gastric upsets and menstrual disturbances were significantly commoner among the women who used the pills orally. These results indicate that for some women vaginal administration of combined pills may be a welcome substitute to oral route, having nearly the same efficacy and lower incidence of certain side effects usually associated with the oral use