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1.
Article Dans Anglais | IMSEAR | ID: sea-148359

Résumé

An accurate and precise developed LCMS method was validated for the determination of pregabalin in human plasma. Validation was carried out according to US FDA guidelines. Validation data showed were within the limits. No matrix effect was found in different sources of human plasma tested. Dilution integrity, Lower limit of quantitation were also within the limit. The Mean extraction recovery of pregabalin was satisfactory.

2.
Indian J Exp Biol ; 2012 July; 50(7): 497-501
Article Dans Anglais | IMSEAR | ID: sea-145281

Résumé

The biodegradation of spent saline bottles, a low density polyethylene product (LDPE) by two selected Arthrobacter sp. under in vitro conditions is reported. Chemical and UV pretreatment play a vital role in enhancing the rate of biodegradation. Treated LDPE film exhibits a higher weight loss and density when compared to untreated films. Arthrobacter oxydans and Arthrobacter globiformis grew better in medium containing pretreated film than in medium containing untreated film. The decrease in density and weight loss of LDPE was also more for pretreated film when compared to untreated film indicating the affect of abiotic treatment on mechanical properties of LDPE. The decrease in the absorbance corresponding to carbonyl groups and double bonds that were generated during pretreatment suggest that some of the double bonds were cut by Arthrobacter species. Since Arthrobacter sp. are capable of degrading urea, splitting of urea group were also seen in FTIR spectrum indicating the evidence of biodegradation after microbial incubation. The results indicated that biodegradation rate could be enhanced by exposing LDPE to calcium stearate (a pro-oxidant) which acts as an initiator for the oxidation of the polymers leading to a decrease of molecular weight and formation of hydrophilic group. Therefore, the initial step for biodegradation of many inert polymers depends on a photo-oxidation of those polymers. The application in sufficient details with improved procedures utilizing recombinant microorganism with polymer degradation capacity can lead to a better plastic waste management in biomedical field. The present plastic disposal trend of waste accumulation can be minimized with this promising eco-friendly technique.

3.
Article Dans Anglais | IMSEAR | ID: sea-137351

Résumé

With the availability of antiretroviral therapy (ART), HIV infection, which was once considered a progressively fatal illness, has now become a chronic treatable condition in children, as in adults. However, the challenges these children are forced to face are far more daunting. The most significant shortcoming in the response to paediatric HIV remains the woefully inadequate prevention of motherto- child transmission (PMTCT), allowing a large number of children to be born with HIV in the first place, in spite of it being largely preventable. In the west, mother-to-child transmission has been virtually eliminated; however, in resource-limited settings where >95 per cent of all vertical transmissions take place, still an infected infants continue to be born. There are several barriers to efficient management: delayed infant diagnosis, lack of appropriate paediatric formulations, lack of skilled health personnel, etc. Poorly developed immunity allows greater dissemination throughout various organs. There is an increased frequency of malnutrition and infections that may be more persistent, severe and less responsive to treatment. In addition, these growing children are left with inescapable challenges of facing not only lifelong adherence with complex treatment regimens, but also enormous psychosocial, mental and neuro-cognitive issues. These unique challenges must be recognized and understood in order to provide appropriate holistic management enabling them to become productive citizens of tomorrow. To address these multi-factorial issues, there is an urgent need for a concerted, sustainable and multipronged national and global response.


Sujets)
Thérapie antirétrovirale hautement active/méthodes , Enfant , Prise en charge de la maladie , Infections à VIH/diagnostic , Infections à VIH/traitement médicamenteux , Infections à VIH/épidémiologie , Infections à VIH/anatomopathologie , Infections à VIH/transmission , VIH-1 (Virus de l'Immunodéficience Humaine de type 1) , Humains , Programmes de vaccination/méthodes , Nourrisson , Transmission verticale de maladie infectieuse/prévention et contrôle
4.
Article Dans Anglais | IMSEAR | ID: sea-51418

Résumé

Treatment planning for patients with skeletal deformities is often considered challenging. This article reports a female patient with achondroplasia who presented with severe maxillary retrognathism and vertical excess along with anterior open bite. The clinical and cephalometric findings of the patient are detailed here. The treatment plan consisted of modified anterior maxillary osteotomy for simultaneous vertical and sagittal augmentation along with orthodontic intervention. The course of surgical-orthodontic treatment and the results are presented. This treatment is to be followed by correction of vertical maxillary excess after completion of growth. This paper concludes that the dentoalveolar component of a skeletal deformity can be handled independent of the craniofacial management.


Sujets)
Achondroplasie/complications , Adolescent , Céphalométrie , Femelle , Humains , Malocclusion de classe III/chirurgie , Maxillaire/malformations , Béance dentaire/chirurgie , Ostéotomie/méthodes , Planification des soins du patient , Mouvement dentaire , Résultat thérapeutique
5.
Article Dans Anglais | IMSEAR | ID: sea-51513

Résumé

Though the management of impacted canine is considered a multi-disciplinary entity requiring the expertise of a number of specialists, the general practitioner needs to coordinate care and must know about the diagnosis and management of canine impaction. The management of canine impactions can be simplified by following a logical and systematic approach. The schematic treatment plan for impacted canines and the factors influencing and determining the plan are discussed in this article.


Sujets)
Protocoles cliniques , Canine/anatomopathologie , Arbres de décision , Humains , Planification des soins du patient , Équipe soignante , Extraction dentaire , Mouvement dentaire , Dent de lait/anatomopathologie , Dent enclavée/classification
6.
Indian J Exp Biol ; 1999 Dec; 37(12): 1241-2
Article Dans Anglais | IMSEAR | ID: sea-58018

Résumé

Anti-steroidogenic activity of various extracts of T. populnea was screened in female albino mice. The weight of the uterus and ovaries were reduced significantly and the cholesterol and ascorbic acid content in ovaries were significantly elevated due to the treatment with extract of T. populnea. The significant inhibition of delta 5, 3 beta hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase, the two key enzymes involved in ovarian steroidogenesis were also observed in mouse ovaries after 15 days of treatment.


Sujets)
Animaux , Oestrogènes/biosynthèse , Femelle , Malvaceae , Souris , Ovaire/effets des médicaments et des substances chimiques , Extraits de plantes/pharmacologie , Progestérone/biosynthèse , Stéroïdes/biosynthèse
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