New purine derivatives with useful plant-growth regulating properties

The corresponding 6-substituted amino-9-aryl-9H-purines 4a-k are synthesized from reactions of 6-chloro-9-[p-anisyl]-or 9-[p- chlorophenyl]-9H-purines 3c and d with primary amines. Products 4d and k are also obtained by fusing 6-methylthiopurines 5 a and b with benzyl and p-anisyl amines. Most of the products 4a-k have been screened for activity as plant-growth regulating factors for wheat plant. Ring closure of 5-acetylamino 1-arylimidazole-4-carboxamides 6 by methanolic sodium hydroxide solution afforded the corresponding 9-aryl 2-methyl-hypoxantlines 7. The action of phosphoryl chloride on the latter products gave their 6-chloro derivatives 8. Treatment of 8b with p-toludine yielded its 9-[p-anisyl]-2-methyl-6-[p-tolylamino] purine 4 I

Synthesis of some new-isoxazolines, isoxazoles and-cyclohexen-ones derived from naphthalene of anticipated pesticidal activity

Naphthalenes are known for their widespread biological activity. Also, the pesticidal and antiviral properties have been reported for some cyclohexenone, isoxazoline and isoxazole derivatives. Such a broad spectrum of biological activities prompted us to synthesise some new isoxazolines, isoxazoles and cyclohexenones bearing the naphthalene moiety for biological evaluation. Thus, it is found in the present investigation that when hydroxyl-amine hydrochloride is allowed to react with 3-aryl-l-[2'-naphthyl]-2-propen-1-ones la-d in boiling pyridine; the oximes 2a-d are obtained, respectively, in good yield

Nitrogenous heterocyclic compounds: some new naphthyl-pyrazolines and their dehydrogenation with tetrachloro-obenzoquinone to the corresponding pyrazoles

Compounds: Some New Naphthyl-Pyrazolines and their Dehydrogenation with Tetrachloro-o-benzoquinone to the Corresponding Pyrazoles SEVERAL pyrazoline and pyrazole derivatives are well known for their bactericidal and fungicidal activities. Also, different pyrazoles are now being used as systematic insecticides as well as insecticide stabilizers. Such a broad spectrum biological activities encouraged us to synthesise newer pyrazolines and -pyrazoles derived from naphthalene for biological evaluation. Thus, in the present investigation, it is found that when 3-aryl-l-[2'-naphthyl]-2-propen-l-ones la-d are allowed to react with hydrazine

Synthesis and quaternization of 5-amino-1-aryl-imidazol-4carboxamides and their related imidazo-pyrazines

Because many amino-imidazoles and some quaternary imidazo lium salts are reported to possess numerous useful biological activities also due to the potential value of many pyrazines as intermediates in the synthesis of the biologically important petridines; the synthesis and quaternization of some new 4 [5]-amino-imidazole-5 [4]-carboxamides and their related imidazo-pyrazines, in the present work, is therefore attempted. Thus, it is found that l-aryl-5-ami no-imidazole-4-carboxamides 3a-d are smoothly obtained, in situ, by a facil ring closure of N-[aryl-formimidate [1] when heated under reflux, in acetonitrile, with 2-amino-2-cyanoacetamide. Meanwhile, compounds 3 are also obtained from the reaction of methyl-N-[carbamoylcyanomethyl]-formimidate [2] with the desired aromatic amine; in the same solvent [Undepressed mixed m.ps.]

Synthesis of some new pyrazolones and benzimidazol-acetonitriles derived from xanthene

Alpha -cyano - [xanthen-9-yl]-hydrazides 2 were cyclised to give 3-amino-4 [substituted-xanthen-9-yl]-pyrazolo-5 [4H] ones 3. Benzimidazole -[9-xanthen] 2-acetonitrilss 7 were formed by condensation of benzimidazole jole-2-acetonitrile with xanthen-9-olea. 3 and 7 were pyrolysed under reduced pressure to give 9-substituted-xanthenes. Various classes of nitrogen hetegocydes such as benzimidazoles, pyrazolones and analogous hetegocydes have been previously prepared and investigated for their biological activities. The aim of this work is to synthesise such compounds in an attempt to obtain newer compounds of anticipated broad spectrum biological activities