Red Cell Storage: Changes And Concern With Blood Transfusion

OBJECTIVES -To study the changes associated with red cell storage and risk associated with blood transfusion. MATERIALAND METHODS -Atotal of 31 whole blood units with CPDA-1 as a preservative were studied for markers of storage lesion along with red cell indices on day 0, day 7, day 14 and day 28 of storage. RESULT- Changes in the levels of total protein, sodium and potassium were statistically significant. There was a gradual reduction in glucose, albumin, and calcium concentration. The overall average daily potassium change of 0.41 mmol/l and sodium change of 0.33 mmol/l over the 28 days period was noticed. CONCLUSION - During storage red cell undergoes several changes affecting survival and function. Clinical effect occurring due to storage lesion in transfused patient needs more studies to be undertaken to see the in vitro effect of red cell storage changes.

Cytomorphological findings and histological correlation of papillary cystadenocarcinoma of the parotid: Not always a low‑grade tumor.

Papillary cystadenocarcinoma (PCAC) is a rare salivary gland tumor characterized by a predominantly cystic growth that often exhibits intraluminal papillary growth without specific histologic features of other cystic salivary gland tumors. The preoperative cytological diagnosis can pose a diagnostic challenge as it has to be differentiated from other cystic papillary tumors such as mucoepidermoid carcinoma, papillary cystic variant of acinic cell carcinoma, and low‑grade cribriform CAC. It is considered to be a low‑grade malignant salivary gland tumor with an indolent biological behavior. We report a case of PCAC of the parotid in a 55‑year‑old male diagnosed on fine needle aspiration cytology. Although it showed mild atypia cytologically, on excision tumor showed vascular and perineural invasion with regional node metastasis indicating a wider morphologic spectrum than what is described. This prompted us to write a case report describing the cytological and histological features of this rare tumor and also discuss the diagnostic challenges.

Serous papillary cystadenofibroma of the fallopian tube: A case report and short review of literature.

Serous papillary cystadenofibromas (SPCAFs) of the fallopian tube are very rare benign tumors of the female genital tract. They are usually asymptomatic and are found incidentally. Until now, only 18 cases of this tumor have been reported in the world literature. We report a case of SPCAF of the left fallopian tube in a 30‑year‑old female who presented with a large abdominal mass and pain. On computed tomography, a diagnosis of ovarian neoplasm was given. However, during surgery the tumor was found to arise from the fallopian tube and was treated with tubal cystectomy with sparing of the ovary. We present this unique case on account of its rarity, unusual presentation, and huge size along with a short review of literature.

Diagnostic dilemma in myoepithelial carcinoma of cheek.

Myoepithelial carcinoma (MC) is a rare neoplasm of the salivary gland generally occurring in the parotid gland and rarely in the minor salivary glands. It poses a diagnostic challenge on fine-needle aspiration (FNA) cytology because it can show different cell types and lack clear features of malignancy. This can lead to a range of differential diagnosis on cytology. The diagnostic difficulty can be compounded if the lesion is present at an unusual site. A 41-year-old male presented with a recurrent swelling on the check since 2 years with a prior history of pleomorphic adenoma (PA) at the same site 8 years back. FNA was performed and a diagnosis of recurrent PA or myoepithelial cell neoplasm was given. Final diagnosis was made on histology and immunohistochemistry studies and reported as MC of minor salivary gland originating within PA. Pathologist should be aware of the occurrence of MC at the sites of the minor salivary glands in the oral cavity and its wide morphologic spectrum to make a confident diagnosis of MC preoperatively.