Diagnosis of resistant strains of Plasmodium Falciparum after chloroquine and amodiaquine therapy from 42 to 72 hours of drug administration

The effect of chloroquine and amodiaquine on the in vivo development of asexual parasites (trophozoide from) during the treatment of falciparum malaria was studied on 48 patients. They consisted of 6 patients who were sensitive, 8 patients with R1 and 6 patients with R11 resistence to chloroquine, and 5 patients who were sensitive, 13 patients with R1 and 10 patients with R11 resistance to amodiaquine. Percentage distribution of tiny, small and large forms of trophozoites were counted every 6 hours till blood smears were negative. From the results we may be able to predict the presence of resistant strains of parasite between 48-72 hours of treatment.