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1.
Article Dans Anglais | IMSEAR | ID: sea-89608

Résumé

Benazepril hydrochloride, a new non-sulfhydryl ACE inhibitor (ACEI) was studied in a titrated dose of 10 mg-20 mg once a day for 6 weeks in 42 mild to moderate adult hypertensive patients with sitting diastolic blood pressure (SDBP) 95-114 mm Hg. The pre-drug SDBP(mean +/- SE) of 102.5 +/- 0.8 mm Hg showed a significant reduction to 87.5 +/- 0.93 mm Hg at the end of treatment. BP was controlled (SDBP < or = 90 mm Hg) in 34 (81%) patients and a drop of at least 10 mm Hg from the pre-treatment SDBP value was noted in 34 (81%) patients. Common adverse reaction was cough in 8(19%) patients. Clinically significant changes in laboratory evaluations were not seen in any patient. Study showed that benazepril in a dose range of 10 to 20 mg per day is an effective agent for treatment of mild to moderate hypertension.


Sujets)
Adulte , Inhibiteurs de l'enzyme de conversion de l'angiotensine/usage thérapeutique , Benzazépines/usage thérapeutique , Pression sanguine/effets des médicaments et des substances chimiques , Femelle , Humains , Hypertension artérielle/traitement médicamenteux , Mâle , Adulte d'âge moyen
3.
Article Dans Anglais | IMSEAR | ID: sea-85272

Résumé

In 102 cases of severe hypertension (DBP > or = 115 mm Hg), with or without acute complications, efficacy and safety of SL Nifedipine 10 mg (NIF), SL Captopril 25 mg (CAP), IV Metoprolol 15 mg (MET) and SL NIF + IV MET were studied in an inpatient trial. Maximum mean percent reduction in SBP was 13.3, 9.7, 15.7 and 19.9 and in DBP was 21.2, 13.9, 12.5 and 20.4 with NIF, CAP, MET and NIF + MET respectively. A safe DBP of < or = 110 mm Hg (Kaplan) was achieved in 90, 61, 72.2 and 95.2 percent of patients. A statistically significant fall in DBP was observed at 5 minutes with all regimens except CAP which was at 15 minutes. Mild side effects observed were palpitations and flushing (NIF n = 4), taste disturbances (CAP n = 3), heaviness of head (CAP n = 1) and giddiness (MET n = 2, NIF + MET n = 2). The trial data suggest that hypertensive crisis can be managed, without intensive care facility, with all four regimens; this implies significant cost containment.


Sujets)
Maladie aigüe , Adolescent , Adulte , Sujet âgé , Antihypertenseurs/effets indésirables , Pression sanguine/effets des médicaments et des substances chimiques , Captopril/effets indésirables , Analyse coût-bénéfice , Association de médicaments , Femelle , Humains , Hypertension artérielle/traitement médicamenteux , Mâle , Métoprolol/effets indésirables , Adulte d'âge moyen , Nifédipine/effets indésirables , Sécurité , Résultat thérapeutique , Vasodilatateurs/effets indésirables
6.
Article Dans Anglais | IMSEAR | ID: sea-90502

Résumé

In an open, non-comparative, variable-dose study, 20 outpatients with mild to moderate essential hypertension were treated with 5-10 mg amlodipine once daily for 4 weeks, after their blood pressures had stabilized on placebo. Amlodipine produced a significant decrease in blood pressure (P < 0.05) from the initial mean of 162/100 mm Hg to 139/85 mm Hg at 4 weeks. 80% of the patients reached the goal diastolic blood pressure of < or = 90 mm Hg with a once-daily dose of 5 mg amlodipine within 2 weeks. The remaining 20% also attained the goal diastolic blood pressure within 4 weeks, with a one-step increase in the dose to 10 mg at 2 weeks. Amlodipine maintained blood pressure reduction throughout the 24-hours dosing interval with a once-daily dose. Notably, no side effects were observed; pulse rate, electrocardiogram, and laboratory parameters were not significantly altered with therapy. Amlodipine in a single daily dose of 5-10 mg is effective and well tolerated in the treatment of patients with mild to moderate hypertension.


Sujets)
Adulte , Sujet âgé , Amlodipine/usage thérapeutique , Pression sanguine/effets des médicaments et des substances chimiques , Femelle , Humains , Hypertension artérielle/traitement médicamenteux , Mâle , Adulte d'âge moyen , Méthode en simple aveugle
8.
Indian J Chest Dis Allied Sci ; 1992 Apr-Jun; 34(2): 85-9
Article Dans Anglais | IMSEAR | ID: sea-30040

Résumé

Eighty-two patients were hospitalized following an accidental exposure to chlorine. All patients presented with dyspnoea and cough. The other symptoms included irritation of throat (53.6%), irritation of eyes (42.3%), headache (29.2%), abdominal pain (26.8%), vomiting (24.3%) and giddiness (9.7%). All of them had bronchospasm and 5 (6%) had cyanosis at the onset. An x-ray of the chest revealed patchy infiltrates in 3 (3.85%) and hilar congestion in 2 (2.44%). Pulmonary function tests showed an obstructive pattern in 27.4%, restrictive in 3.25% and mixed in 53.2%. Pulmonary functions were normal in 16.1% of the patients. Bronchoscopy revealed tracheobronchial mucosal congestion in all cases, hemorrhagic spots in 35.7%, erosions and ulcers in 12.5%. All patients were treated with oxygen, aminophylline, hydrocortisone and antibiotics. Haematemesis (n = 1) and pulmonary oedema (n = 2) developed 12 hours after the admission. Two other patients developed pneumonia 48 hours later. All patients recovered satisfactorily. On follow-up 16 patients had no sequelae after one year. Pulmonary functions were normal in 5 patients after 3 years of follow-up.


Sujets)
Adulte , Chlore/intoxication , Femelle , Études de suivi , Humains , Inde , Maladies pulmonaires/induit chimiquement , Mâle , Adulte d'âge moyen
9.
Indian Heart J ; 1990 Sep-Oct; 42(5): 385-7
Article Dans Anglais | IMSEAR | ID: sea-2762

Résumé

Two young female patients aged 12 and 20 years with homozygous familial hypercholesterolaemia are presented with autopsy reports. Both had extensive coronary artery disease with myocardial infarction and tendon xanthomas. The first case had additional aortic stenosis.


Sujets)
Adulte , Sténose aortique/étiologie , Enfant , Maladie coronarienne/étiologie , Femelle , Homozygote , Humains , Hyperlipoprotéinémie de type II/sang , Infarctus du myocarde/étiologie , Xanthomatose/étiologie
11.
Article Dans Anglais | IMSEAR | ID: sea-87941

Résumé

Nifedipine, a calcium channel blocker exerts significant peripheral vasodilatory activity in hypertensive patients. It has been postulated that the antihypertensive effect of peripherally acting vasodilators is masked, by counter regulatory mechanism e.g. activation of renin-angiotensin aldosterone (RAA) axis. The present work was undertaken to study the effect of blockade of RAA axis using captopril, an angiotensin converting enzyme inhibitor on the blood pressure lowering activity of nifedipine. Pretreatment with captopril in a dose of 25 mg. bd was carried out for 4 weeks in one group of 10 patients before administering nifedipine 10 mg bd for 4 weeks. The other matched group of 10 patients received nifedipine alone in the same dose. It was observed that although captopril by itself had no appreciable effect on blood pressure in the dose used, it significantly enhanced the blood pressure lowering activity of nifedipine. It appears that counterregulatory mechanisms play an important role in determining the net antihypertensive effect of peripheral vasodilators.


Sujets)
Adulte , Sujet âgé , Captopril/pharmacologie , Interactions médicamenteuses , Humains , Hypertension artérielle/traitement médicamenteux , Adulte d'âge moyen , Nifédipine/pharmacologie
17.
Indian J Med Sci ; 1967 Dec; 21(12): 831-3
Article Dans Anglais | IMSEAR | ID: sea-67896
19.
Indian J Med Sci ; 1965 Jul; 19(): 529-49
Article Dans Anglais | IMSEAR | ID: sea-68774
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