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Article Dans Anglais | IMSEAR | ID: sea-181041

Résumé

Background: Thromboembolism can complicate Fontan surgery. There are few well designed studies in the literature to determine the epidemiology of thrombosis after Fontan. Methods: We report the experience of King Faisal Specialist Hospital & Research Center- Jeddah, Kingdom of Saudi Arabia; regarding thrombosis of extra-cardiac Fontan pathways in 3 of our patients; two patients were post- Fontan operation and one patient was post- Kawashima procedure & hepatic vein incorporation. Results: The first and second patients developed thrombosis of Fontan pathways at one month & one year postoperatively respectively. In both patients, stenting of the extra-cardiac contegra reestablished the patency of Fontan circuit and saved the risks of redo-surgeries. In the third patient, conduit occlusion was diagnosed 5 months postoperatively. Several attempts of cardiac catheterizations failed to penetrate the thrombosed conduit. Surgical re-intervention was inevitable. Conclusions: The threshold for diagnostic and interventional cardiac catheterization should be lowered in post Fontan operation. Chronic oral anticoagulation may not prevent development of thrombosis despite therapeutic international normalized ratio (INR).

2.
Indian Heart J ; 2005 May-Jun; 57(3): 261-4
Article Dans Anglais | IMSEAR | ID: sea-6136

Résumé

Inadvertent and accidental epinephrine overdose might result in potentially lethal complications. We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously. He developed significant ischemic changes in standard 12-lead electrocardiogram, transiently raised cardiac enzymes, reduced left ventricular systolic function, pulmonary edema and pulmonary hemorrhage. It is suggested that special precautionary measures should be taken regarding the dose and the route while administering epinephrine to avoid mishaps.


Sujets)
Maladie aigüe , Adolescent , Relation dose-effet des médicaments , Électrocardiographie , Épinéphrine/effets indésirables , Études de suivi , Humains , Hypersensibilité/traitement médicamenteux , Immunoglobulines par voie veineuse/effets indésirables , Perfusions veineuses , Mâle , Erreurs de médication , Ischémie myocardique/induit chimiquement , Appréciation des risques , Immunodéficience combinée grave/diagnostic , Résultat thérapeutique
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