Résumé
Background and Objectives: Diabetes mellitus (DM) has become the leading chronic disorders in nearly all countries due to urbanization, changing lifestyles and lack of physical activity. Neuropathy is the commonest and most debilitating complications of diabetes. Diabetic Peripheral Neuropathy (DPN) increases balance impairment, increasing fall risk. Consequences include decline in mobility, avoidance of activity, institutionalization and mortality; thus affecting one’s Quality of Life (Quality of Life). Previous studies have focused on balance impairment and fall risk in DPN patients and also on QoL separately. Thus, the aim of this study is to find the effect of balance impairment and fall risk on QoL. Methods: A correlational study was done on 30 DPN patients, selected by purposive sampling technique. Subjects were screened for neuropathy using Toronto Clinical Neuropathy Scoring System (TCSS) and those fulfilling the inclusion criteria, underwent balance and fall risk assessment by Berg Balance Scale (BBS) and Timed Up and Go (TUG) Test respectively. Following which, neuropathy specific quality of life questionnaire (NeuroQoL) was administered to evaluate their QoL. Results obtained were statistically analysed using SPSS 16.0, MS Word and MS Excel. Pearson’s correlation was used to find the correlation between variables. Results: The results showed statistically significant correlation between all the variables. Correlation between BBS and reduction in QoL (r=-0.540, p=0.002), TUG and reduction in QoL (r=0.531, p=0.003). Conclusion: In conclusion, physical limitations such as balance impairment and greater fall risk significantly reduces DPN patient’s QoL.
Résumé
A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of Tinidazole and Ciprofloxacin in Tabletdosage form. An Aligant Zorbax Rx-C18 5μ column having 150 x 4.6mm id in Isocratic mode with mobile phase containing Orthophosphoric acid: methanol (70:30 %v/v pH: 3.0) was used. The flow rate was 1.5ml/min and effluents were monitored at 225nm.) The retention time of Tinidazole and Ciprofloxacin was 2.3min and 7.2min respectively.The concentration curves of Tinidazole and Ciprofloxacin were linear in the concentration range of 150-450 μg/mL and 125-375μg/mL respectively. The developed method was validated for specificity, precision, linearity, accuracy, LOD,LOQ, robustness . Recovery of Tinidazole and Ciprofloxacin in formulations was found to be in the range of 97.0% -98.0% and 100%-103% respectively confirms the non-interferences of the excipients in the formulation. Due to its simplicity, rapidness and high precision, the proposed HPLC method may be used for the simultaneous determination of these two drugs in pharmaceutical dosage forms.