Gastric perforation in very low birth weight infants following indomethacin administration: 2 case reports.

Two very low birth weight infant who had received intravenous Indomethacin for closure of ductus arteriousus developed massive pneumoperitoneum on the first and fifteenth day after administration. Isolated gastric perforation, sparing the entire intestine was found on laparotomy. Pathological findings in the first case shows transmural hemorrhage without inflammation. This report aims to discuss the contribution that Indomethacin makes in the pathogenesis of intestinal perforation in newborn patients.