Résumé
Two trials of external quality assessment for conventional newborn screening tests for phenylketonuria, congenital hypothyroidism, galactosemia, maple syrup urine disease and homocytinuria and for the newborn screening tests using tandem mass spectrometry (MS/MS) were performed in 2009. Total 20 specimens were distributed to 13 laboratories. All the control materials were send as dried blood spots. The response rate was 100%. The mean, SD, CV, median and range were analyzed. In addition, two trials of external quality assessment for glycohemoglobin (HbA1c) were performed in 2009. Total 6 samples were distributed to 196 laboratories and the response rate was 97.2% (175/180) and 98.5% (193/196) in each trial. From this trial, we performed accuracy-based survey which used challenge specimens that were free from matrix effects and had target values traceable to certified reference material. Bias between each participants result and reference target value were evaluated.
Sujets)
Humains , Nouveau-né , Biais (épidémiologie) , Hypothyroïdie congénitale , Galactosémies , Corée , Leucinose , Dépistage de masse , Phénylcétonuries , Spectrométrie de masse en tandemRésumé
Two trials of external quality assessment for the newborn screening tests of inborn errors of metabolism including PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen and homocytinuria screen and newborn screening tests using tandem mass spectrometry were performed in 2008. Total 20 specimens for the newborn screening tests were distributed to 14 laboratories. The response rate was 100%. All the control materials were sent as dried blood spot forms. The mean, SD, CV, median and range were analyzed. The newborn screening tests using tandem mass spectrometry (MS/MS) were analyzed that the participants results for amino acids, acylcarnitine and their cutoff values. In addition, two trial of external quality assessment for glycohemoglobin (HbA1c) was performed in 2008. Total five samples were distributed to 238 laboratories and the response rate was 95.8% (228/238) and 97.4% (225/231), in each. Statistical data such as mean, SD and CV were provided for peer groups.
Sujets)
Humains , Nouveau-né , Acides aminés , Carnitine , Galactosémies , Corée , Leucinose , Dépistage de masse , Erreurs innées du métabolisme , Groupe de pairs , Spectrométrie de masse en tandemRésumé
Two trials of external quality assessment for the newborn screening tests of inborn errors of metabolism including PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen and homocytinuria screen, were performed in 2007. Total 20 specimens for the newborn screening tests were distributed to 16 laboratories. The response rate was 100%. All the control materials were sent as filter paper forms. The mean, SD, CV, median and range were analyzed. From this trial, the proficiency tests for newborn screening tests using tandem mass spectrometry (MS/MS) were included as routine quality assessment. Participants results for amino acids, acylcarnitine and their cutoff values were analyzed. In addition, the trial of external quality assessment for glycohemoglobin (HbA1c) was first started in 2007. Two samples prepared from normal whole blood and commercially available abnormal control materials, were distributed to 246 laboratories and the response rate was 93%. Statistical data such as mean, SD and CV were provided for peer groups.
Sujets)
Humains , Nouveau-né , Acides aminés , Carnitine , Galactosémies , Corée , Leucinose , Dépistage de masse , Erreurs innées du métabolisme , Groupe de pairs , Spectrométrie de masse en tandemRésumé
Two trials of external quality assessment for the newborn screening tests of inborn errors of metabolism including PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen and homocytinuria screen, were performed in 2007. Total 20 specimens for the newborn screening tests were distributed to 16 laboratories. The response rate was 100%. All the control materials were sent as filter paper forms. The mean, SD, CV, median and range were analyzed. From this trial, the proficiency tests for newborn screening tests using tandem mass spectrometry (MS/MS) were included as routine quality assessment. Participants results for amino acids, acylcarnitine and their cutoff values were analyzed. In addition, the trial of external quality assessment for glycohemoglobin (HbA1c) was first started in 2007. Two samples prepared from normal whole blood and commercially available abnormal control materials, were distributed to 246 laboratories and the response rate was 93%. Statistical data such as mean, SD and CV were provided for peer groups.
Sujets)
Humains , Nouveau-né , Acides aminés , Carnitine , Galactosémies , Corée , Leucinose , Dépistage de masse , Erreurs innées du métabolisme , Groupe de pairs , Spectrométrie de masse en tandemRésumé
The trial of external quality assessment for inborn error of metabolism was performed in 2005. Total 11 specimens for the conventional newborn screening tests were distributed to 47 laboratories. The response rates were 92.5% (37/40) and 100% (47/47), in each trial. All the control materials were sent as filter paper forms. Each laboratory replied the test results of the screening items that they were doing as a routine test at the reception of the specimen among PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen, homocystinuria screen and histidinemia screen. The mean, SD, CV, median and range were analyzed. The pilot proficiency test for newborn screening using tandem mass spectrometry (MS/MS) was also performed. Total 8 blood spots were distributed to 9 laboratories performing newborn screening using MS/MS. Participants' results for amino acids & acylcarnitine and their cutoff values were analyzed.
Sujets)
Humains , Nouveau-né , Acides aminés , Galactosémies , Homocystinurie , Corée , Leucinose , Dépistage de masse , Métabolisme , Spectrométrie de masse en tandemRésumé
The trial of external quality assessment for inborn error of metabolism was performed twice in 2004. Total 10 specimens for the conventional newborn screening tests were distributed to 43 laboratories. The response rates were 90.7%(39/43) in first trial and 90%(36/40) in second trial. All the control materials were sent as filter paper forms. Each laboratory replied the test results as the screening items they were doing as a routine test at the reception of the specimen among PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen, homocytinuria screen and histidinemia screen. The mean, SD, CV, median and range were analyzed. From this trial, pilot proficiency test for newborn screening using tandem mass spectrometry (MS/MS) was also performed. Total 8 blood spots were distributed to 7 laboratories performing newborn screening using MS/MS. Participants results for amino acids & acylcarnitine and their cutoff values were analyzed.
Sujets)
Humains , Nouveau-né , Acides aminés , Galactosémies , Corée , Leucinose , Dépistage de masse , Métabolisme , Spectrométrie de masse en tandemRésumé
The trial of external quality assessment for inborn error of metabolism was performed in 2003. A total 10 specimens for neonatal screening tests were distributed to 43 laboratories with a response rate of 83%. All the control materials were sent as a filter paper form. Each laboratory replied the test result as the screening items they were doing as a rountine test at the reception of the specimen among PKU screening, neonatal TSH, neonatal T4(total/free), galactosemia screen, homocytinuria screen and histidinemia screen. The mean, SD, and CV were analyzed.
Sujets)
Nouveau-né , Galactosémies , Corée , Dépistage de masse , Métabolisme , Dépistage néonatalRésumé
The trial of external quality assessment for inborn error of metabolism was performed in 2002. Total 10 specimens for neonatal screening tests were distributed to 61 laboratories with a response rate of 70.5%(43/61). All the control materials were sent as filter paper forms. Each laboratory replied the test results as the screening items they were testing routinely at the reception of the specimen among PKU screening, TSH, T4 (total/free), galactosemia screen, maple syrup urine disease screen, homocytinuria screen and histidinemia screen. The mean, SD, CV, median and range were analyzed.