Comparison of the cardiovascular effects of nalbuphine hydrochloride and naloxone hydrochloride following induces haemorrhagic shock in cats

The cardiovascular effects of opioid mixed agonistantagonist, nalbuphine hydrochloride and opioid antagonist, naloxone, have been evaluated in anaesthetized cats following the induction of hypovolaemia. The mean arterial pressure in anaesthetized cats decreased by about 39 +/- 0.5 mmHg following a haemorrhage of 40% of their blood volume. An intravenous infusion of nalbuphine [0.5 mg/kg/min for 4 min.] or naloxone [0.5 mg/kg/min. for 4 min.] partially restored blood pressure. Thus in experimental animal models of harmorrhagic shock, nalbuphine has similar cardiovascular profile to naloxone. The established analggesic activity of nalbuphine may confer an dvantage in some shock states