effect of diazoxide of theophylline on blood glucose and liver cyclic amp levels during endotoxemia in mice

The effect of diazoxide or theophylline on blood glucose and liver cyclic AMP levels during endotoxaemia in mice were compared. Administration of endotoxin resulted in a decrease in both parameters after eight and twelve hours. Diazoxide administered at seven hours post- endotoxin improved blood glucose and liver cyclic AMP levels at both eight and twelve hours post-endotoxin. Theophylline administration, using the same time schedule, increased liver cyclic AMP level but increased blood glucose slightly. Differences in the effect of both drugs is probably due to their possible different effect on insulin release