RÉSUMÉ
Objective To obtain the ratcheting strain of articular cartilage under different loading conditions, and construct the theoretical model so as to predict the ratcheting strain of cartilage. Methods The fresh articular cartilage obtained from the trochlear of distal femur was used as experimental subject. The ratcheting strain of articular cartilage was tested under cyclic compressive loads by applying the non-contact digital image correlation technique. The theoretical model was constructed to predict the ratcheting strain of articular cartilage with different stress amplitudes and stress rates. The results from predictions were compared with the experimental results. Results The ratcheting strain of cartilage increased rapidly at initial stage and then showed the slower increase with cycles increasing. The ratcheting strain increased with stress amplitude increasing when the stress rate was constant. However, the ratcheting strain decreased with stress rate increasing when the stress amplitude was constant. When the stress rate increased, the ratcheting stain decreased. The prediction results of the established theoretical model were in good agreement with experimental results. Conclusions The ratcheting strain of articular cartilage is proportional to the stress amplitude, and inversely proportional to the stress rate. The established theoretical model can predict the ratcheting strain of articular cartilage and provide guidance for the construction of tissue engineered artificial cartilage.
RÉSUMÉ
Objective To obtain the ratcheting strain of articular cartilage under different loading conditions,and construct the theoretical model so as to predict the ratcheting strain of cartilage.Methods The fresh articular cartilage obtained from the trochlear of distal femur was used as experimental subject.The ratcheting strain of articular cartilage was tested under cyclic compressive loads by applying the non-contact digital image correlation technique.The theoretical model was constructed to predict the ratcheting strain of articular cartilage with different stress amplitudes and stress rates.The results from predictions were compared with the experimental results.Results The ratcheting strain of cartilage increased rapidly at initial stage and then showed the slower increase with cycles increasing.The ratcheting strain increased with stress amplitude increasing when the stress rate was constant.However,the ratcheting strain decreased with stress rate increasing when the stress amplitude was constant.When the stress rate increased,the ratcheting stain decreased.The prediction results of the established theoretical model were in good agreement with experimental results.Conclusions The ratcheting strain of articular cartilage is proportional to the stress amplitude,and inversely proportional to the stress rate.The established theoretical model can predict the ratcheting strain of articular cartilage and provide guidance for the construction of tissue engineered artificial cartilage.
RÉSUMÉ
Objective To obtain the ratcheting strain of articular cartilage under different loading conditions,and construct the theoretical model so as to predict the ratcheting strain of cartilage.Methods The fresh articular cartilage obtained from the trochlear of distal femur was used as experimental subject.The ratcheting strain of articular cartilage was tested under cyclic compressive loads by applying the non-contact digital image correlation technique.The theoretical model was constructed to predict the ratcheting strain of articular cartilage with different stress amplitudes and stress rates.The results from predictions were compared with the experimental results.Results The ratcheting strain of cartilage increased rapidly at initial stage and then showed the slower increase with cycles increasing.The ratcheting strain increased with stress amplitude increasing when the stress rate was constant.However,the ratcheting strain decreased with stress rate increasing when the stress amplitude was constant.When the stress rate increased,the ratcheting stain decreased.The prediction results of the established theoretical model were in good agreement with experimental results.Conclusions The ratcheting strain of articular cartilage is proportional to the stress amplitude,and inversely proportional to the stress rate.The established theoretical model can predict the ratcheting strain of articular cartilage and provide guidance for the construction of tissue engineered artificial cartilage.
RÉSUMÉ
Objective To obtain distributions of normal displacement on different layers of articular cartilage under sliding loads and investigate effects of compressive strain, sliding rate and sliding numbers on depth-dependent normal displacement of articular cartilage. Methods The non-contact digital image correlation (DIC) technique was applied to investigate the normal displacement of different layers for fresh pig articular cartilage under sliding loads, respectively. ResultsThe largest normal displacement was found on the superficial layer, while that on the deep layer was the smallest, with the middle layer was in between under sliding loads. The normal displacement for cartilage at different normalized depth increased with compressive strain increasing and the largest increasing amplitude was in the superficial layer. The depth-dependent normal displacement for cartilage decreased with sliding rates increasing. The normal displacement for cartilage kept increasing with different sliding numbers within its sliding time. The most significant increasing amplitude of normal displacement was found between the first and second slide. Conclusions Under sliding loads, the normal displacement of cartilage usually changes along with its depth from surface to deep layer, and compressive strain, sliding rate and sliding numbers all play important roles in such normal displacement distributions on different layers. These results can provide the basis for clinical cartilage disease treatment and cartilage defect repair, and are also important for structure and construction of artificial cartilage as well as in mechanical function evaluation.
RÉSUMÉ
Objective To investigate the loading rate-dependent property of different layers for articular cartilage by unconfined compression testing on articular cartilage at different loading rates. Methods The non-contact digital image correlation (DIC) technique was applied to investigate the mechanical properties of different layers for fresh pig articular cartilage at different loading rates. Results At constant loading rate, the compressive strain of superficial layer and deep layer was the largest, while that of middle layer was in between under the same compressive stress. The Poisson’s ratio increased from superficial layer to deep layer along with cartilage depth increasing. The stress-strain curves of cartilage were different at different loading rates, indicating that the mechanical properties of cartilage were dependent on the loading rate. The elastic modulus of cartilage increased with loading rates increasing, and the compressive strains of different layers decreased under the same compressive stress with loading rates increasing. Conclusions The compressive strain decreased while the Poisson’s ratio increased from superficial layer to deep layer along the cartilage depth. The mechanical properties of different layers for cartilage were dependent on the loading rate. This study can provide the basis for clinical cartilage disease prevention and treatment, and is important for mechanical function evaluation of artificial cartilage as well.
RÉSUMÉ
Objective To investigate the mechanical properties of both artificial cartilage and host cartilage by establishing the in vitro model of tissue engineered cartilage for repairing defects. Methods The agarose gel as an artificial cartilage was implanted in a deep cartilage defect connected with biological adhesive to set up the in vitro model of tissue engineered articular cartilage defects. Under the compression load, the instant mechanical behavior of the repair area was studied using the digital image correlation technology. Results There was no cracking phenomenon occurred at the interface during the compression process. The Strain distributions at middle layer of the repair area were obtained when the cartilage thickness appeared changes with 3.5%, 5.6%, 7.04% and 9.0% by the compression, respectively. When the compressing change increased from 3.5% to 9%, the maximum compressive strain of host cartilage was increased by 75.9%, and the maximum tensile strain of artificial cartilage was increased by 226.99% in the vertical direction of cartilage surface. In the direction parallel with cartilage surface, the maximum tensile strain at the interface was increased by 116.9%, and the increment was far more than that at the host cartilage area and artificial cartilage area. For shear strain at the repair area, the direction of shear strain at the interface changed oppositely with the compression increasing. Conclusions The repair effect of tissue engineered cartilage was uncertain due to the mechanical environment of the repair area. After the tissue engineered cartilage was implanted in the defect, the repair area was under the influence of complex strain states. The strains changed greatly at the interface both with the host cartilage and artificial cartilage as the compression increasing. The strain in the vertical direction of cartilage surface at the interface might change from compressive stain to tensile strain, which was significantly increased in the direction parallel with cartilage surface. The strain direction at the interface could even be changed oppositely, and the shear strain appeared rapidly increase. The complex strain states lead to such great changes in mechanical environment of the defect area, and may cause cracking at the interface, and even further affect the repair process. Therefore, attention should be given to this complex mechanical environment during cartilage defect repair process in clinical treatment.